I have read that some patients have trouble with Avandia either causing weight gain, or giving them a hard time losing. I'm really not sure what the difference is with the drugs, but all I can tell you is that I have been on met now for 19 months, and I really believe it has helped me feel better...even before I lost a lot of weight. The trick to all of this, in my experience and that of other cysters has been that you must make the lifestyle change as well as taking the drug to see the best results you can. Eating a diet that is lower in carbs definitely makes a difference. If you feel that the avandia isn't helping much, perhaps try glucophage or met, and see if you don't have better results. For some, it does seem to make a difference!
