I take metformin and spironolactone, together, after dinner. The metformin is extended release (take it all at once daily). I also take a spironolactone with breakfast, since I take 2 doses. I haven't noticed any odd reactions with the combination, but metformin alone does a number on me if I wait too long to eat breakfast in the morning (like if I sleep in).
I hope you find out soon what is giving you side effects. |