Neechogan,
It is very important for many reasons for you wife to take her Metformin. I also want to recommend a couple books for you to read. They are by Dr. Elizabeth Vliet, and the ones I have are the following:
Women, Weight and Hormones
It's my Ovaries, Stupid! (I love that title)
Savvy Woman's Guide to PCOS
They are all very good books, and cover somewhat different aspects of women's hormones.
What Dr. Vliet does mention on her books that she likes to do is start medications at a low dose, and slowly increase them. That way, the patient avoids many side-effects of medications when it's done this way. So, instead of your wife being put on 500mg Metformin TID(not sure of dose), maybe they start her out on 250mg once or twice a day until her body adjusts to that dose, and gradually increase her dose over a few weeks. I have read about this in her books, and she gives more exact doses than I can, as I haven't been put on Metformin, yet. Her motto for medication is, "Start low and go slow". Have your wife try Metformin in that way, and see if it helps.
Kaylene |