I didn't read through this entire thread, so forgive me if this has been mentioned. I was reading over on Dr. Coulam's board (INCIID reprod. immun.) that insulin resistance has a genetic relationship with the PAI-1 mutation. I haven't even delved into that. I have a history of over 20 years of intermittent joint pain, but the past 2 years is when the insulin resistance cropped up and the joint pain worsened. I've also got the gene for HLA-B27 (ankylosing spondylosis & other immune disorders). They've yet to diagnose me with anything. Although after a recent m/c I just found out my blood is clotting too fast. I suspect my APA's are going to come back positive this time. It seems like everything worsened at one time after doing some steroids during IVF & then taking a supplement that is a type of immunoglobulin. I really think there is a autoimmune component & maybe that causes some kind of gene mutation. But really I'm baffled by it all. My sed rate & c-reactive protein were also high like a pp mentioned, for a year. Previously they were normal. And seems they've finally come back down again.
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Wendy
TTC our #1 for 12 yrs
Me - 18yo DS from previous marriage
DH - no children
4 IVF's
5 early losses
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Last m/c July 2007 5w6d
Dx non-trad PCO in 3/07(no cysts), arthritis
PH diet, lots of veg/fruit & magnesium, DHA (algae), Nattokinase, Saw Palmetto, Moducare
Dx 10/07 - prothrombin mutation (clotting disorder)
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