When I first started Synthroid several years ago, it didn't make a difference in my cycles. But I also had thyroid cancer (unknown at the time). Once we got my thyroid under control though, I am pretty close to clockwork.
It should make a difference if that is the only thing wrong. Sometimes getting your thyroid back in check can really help your PCOS (like it did for me), but other times there are other factors too that you will need to correct as well.
Cynthia
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Proud Marine Wife
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Proud Mom of DS (3 yrs) born in Korea AND
DS2 (17 mo) waiting for us in Korea! (traveling June 10!!)
Thyroid Cancer Survivor since 09 April 2004
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