the dose of flutamide in the study was
250mg twice per day= 500mg/day....
Also, Kat I didn't emphasize the diet aspect of the study because I was mainly thinking of Flutamide in relation to the hairloss issue, not necessarily focusing on the Metformin which addresses the insulin issues.
Flutamide does not affect the insulin levels as remarked in this study:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
In addition to the reproductive consequences, polycystic ovary syndrome (PCOS) is characterized by a metabolic disorder in which hyperinsulinemia and insulin resistance are central features. The effects and possible benefits from insulin-sensitizing drugs are not well known, especially in non-obese women with PCOS. This
study was designed to evaluate the effects of metformin and flutamide on metabolic parameters and insulin resistance in non-obese women with PCOS. Thirty non-obese women newly diagnosed with PCOS and 15 age- and weight-matched healthy volunteers as controls were included in the study. Patients were assigned randomly to receive
flutamide 250 mg daily or metformin 850 mg three times daily. Glucose, insulin, insulin resistance, androgen levels and glucose and insulin responses to an oral glucose tolerance tests (OGTT) were assessed before and after a 4-week therapy period. A positive correlation was found between body mass index and insulin level in patients with PCOS and controls. Follicle stimulating hormone, luteinizing hormone, free testosterone and dehydroepiandrosterone sulfate levels decreased significantly, but
insulin resistance levels were not changed after flutamide therapy. Body weight, free testosterone, insulin and insulin resistance levels decreased significantly after metformin therapy. In conclusion, metformin treatment improved insulin sensitivity and decreased androgen levels, and flutamide decreased androgen levels but failed to improve insulin sensitivity in the non-obese women with PCOS.
PMID: 15697072 [PubMed - indexed for MEDLINE]
These two drug works synergistically but have different actions on different hormone systems.... this is so incredibly interesting isn't it...
