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Old 11-26-2008, 08:29 PM   #9 (permalink)
mloverstreet
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*My biochemistry degree is about to show, lol*

Clomid works by telling the estrogen receptors in your hypothalamus that your body lacks estrogen. Your body says, "Whoa! Make more!" You get an estrogen surge, follicles grow, eggs develop, and hopefully the magic happens.

Femara is an aromatase inhibitor. Basically it keeps your body from converting estrogens into androgens (a big problem for PCOS'ers.) It causes low estrogen levels so your body reacts by making more estrogen and hopefully causing your ovaries to function properly.

Femara has a super short half-life and flushes out of your system pretty quickly. Clomid, yeah, not so much. It tends to stick around in your system for weeks which is why back to back to back to back cycles can cause side effects like dry CM and poor uterine linings.

That's the difference in a nutshell.
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