Quote:
Originally Posted by bronconole  I brought my doc a very large study published that my sis in law gave me (Ph.D at FSU) and he did acknowledge that people debate using met but many in the states feel that it does help and is worth the try. |
Helps what?
From a medical standpoint, that doesn't really mean
anything.
Exercise '
helps' - and there's no debate or controversy there...but you don't see nearly enough women with pcos exercising the recommended 300 minutes per week - especially since they hope a 'pill' will do the job (which it won't)
The point of the article is this: While met 'helps' women ovulate, it didn't result in more successful PREGNANCIES.
And based on the review of the literature, the 'ideal' course of treatment for women ttc w/ pcos is:
Quote:
The recommended first-line treatment for ovulation induction remains the anti-estrogen clomiphene citrate (CC).
Recommended second-line intervention, should CC fail to result in pregnancy, is either exogenous gonadotrophins or laparoscopic ovarian surgery (LOS). The use of exogenous gonadotrophins is associated with increased chances for multiple pregnancy and, therefore, intense monitoring of ovarian response is required. LOS alone is usually effective in <50% of women and additional ovulation induction medication is required under those circumstances. Overall, ovulation induction (representing the CC, gonadotrophin paradigm) is reported to be highly effective with a cumulative singleton live birth rate of 72%.
Recommended third-line treatment is in vitro fertilization.
|
Again, those are just 'RECOMMENDATIONS', as the article also goes on to say this:
Quote:
More patient-tailored approaches should be developed for ovulation induction based on initial screening characteristics of women with PCOS.
Such approaches may result in deviation from the above mentioned first-, second- or third-line ovulation strategies in well-defined subsets of patients. |
Bottom line, however, in terms of RECOMMENDED course of treatment:
Quote:
Metformin use in PCOS should be restricted to women with glucose intolerance.
Based on recent data available in the literature, the routine use of this drug in ovulation induction is not recommended.
|
Also of interest>>
STUDY: PCOS w/ desire for children- lifestyle change ESSENTIAL for treatment to work