PCOS Message Board - View Single Post - Nizoral shampoo to help with hairloss (Nizoral is a otc dandruff shampoo)

Kora · 08-27-2009, 06:15 PM

This one is done on rats

Quote:

Accession number;05A0392694

Title;Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice

Author;JIANG JU(Juntendo Univ. School Of Medicine, Tokyo, Jpn) TSUBOI RYOJI(Tokyo Medical Univ., Tokyo, Jpn) KOJIMA YUKO(Juntendo Univ., Tokyo, Jpn) OGAWA HIDEOKI(Juntendo Univ. School Of Medicine, Tokyo, Jpn)

Journal Title;J Dermatol

Journal Code:Z0757A

ISSN:0385-2407

VOL.32;NO.4;PAGE.243-247(2005)

Figure&Table&Reference;FIG.2, REF.23

Pub. Country;Japan

Language;English

Abstract;Ketoconazole (KCZ) is an imidazole anti-fungal agent that is also effective in topical applications for treating seborrheic dermatitis and dandruff. Recently, topical use of 2% KCZ shampoo has been reported to have had a clinically therapeutic effect on androgenetic alopecia. The present study was conducted with the purpose of quantitatively examining the stimulatory effect of KCZ on hair growth in a mouse model. Coat hairs on the dorsal skin of seven week-old male C3H/HeN mice were gently clipped, and either 2% KCZ solution in 95% ethanol or a vehicle solution was topically applied once daily for three weeks. The clipped area was photographed, and the ratio of re-grown coat area was then calculated. The results demonstrated that 2% KCZ had a macroscopically significant stimulatory effect compared with the vehicle group (p<0.01, n=10). Repeated experiments showed similar effects, confirming the efficacy of KCZ as a hair growth stimulant. Although the therapeutic mechanism of topical KCZ for hair growth is unclear, our results suggest that topical applications of the substance are useful for treating seborrheic dermatitis accompanied by hair regression or male pattern hair loss. (author abst.)