Are All PCOSers At Risk for Diabetes? Study Says, "No"
Eur J Endocrinol. 2004 Apr;150(4):525-32. The polycystic ovary syndrome per se is not associated with increased chronic inflammation
Mohlig M, Spranger J, Osterhoff M, Ristow M, Pfeiffer AF, Schill T, Schlosser HW, Brabant G, Schofl C.
Department of Clinical Nutrition, German Institute of Human Nutrition, 14558 Potsdam-Rehbruecke, Germany.
CONCLUSIONS: In PCOS women, plasma levels of IL-6 and CRP were not increased when compared with age- and BMI-matched controls. BMI was, however, the parameter most strongly related to IL-6 and CRP in PCOS; thus PCOS-related endocrine abnormalities do not appear to activate inflammatory parameters thereby enhancing the risk of diabetes. In PCOS, the type 2 diabetes risk may, therefore, be confined to those with obesity and/or metabolic alterations rather than affecting all women suffering from the syndrome.
OBJECTIVE: The syndrome of polycystic ovaries (PCOS) is a known risk factor for type 2 diabetes. It is not known, however, whether the increase in diabetes risk is related to endocrine abnormalities associated with PCOS such as hyperandrogenemia, or whether it is a consequence of the anthropometric or metabolic alterations frequently observed in PCOS women.
DESIGN: Since markers of inflammation are supposed to predict type 2 diabetes, interleukin-6 (IL-6) and C-reactive protein (CRP) in combination with parameters of obesity, insulin resistance and hyperandrogenism were determined in 57 PCOS women and in 20 age-matched healthy controls. In addition, the C-174G IL-6 promoter polymorphism was analyzed as a determinant in influencing IL-6, obesity, and androgen levels in women.
RESULTS: Neither CRP nor IL-6 were significantly elevated in lean or obese PCOS women compared with age-matched lean or obese controls. In PCOS patients, variables of body composition (body mass index (BMI), waist to hip ratio, dual-energy X-ray-absorptiometry fat mass) and of insulin resistance were correlated with IL-6 or CRP, while parameters of hyperandogenism were not. Multivariate linear regression analysis revealed that obesity is the dominant force, thus explaining 18% and 24% of the IL-6 or CRP levels, respectively, in PCOS women. No association of IL-6 or BMI to a certain genotype at C-174G could be demonstrated in 50 PCOS patients. The heterozygous GC genotype, however, was associated with lower androstendione levels. Metformin treatment of 9 obese, insulin-resistant PCOS patients over a period of 6 months caused a significant decrease in body weight, body fat mass and total testosterone, but showed no significant decline in IL-6 or CRP concentrations.
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Hey, SoulCysters! Need to eat more veggies, but can't find recipes??
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but isn't this like saying 'you aren't at increased risk for diabetes unless you have IR/weight issues.. yet you have IR/weight issues because of PCOS so ... ' it just doesn't seem like a profound statement, unless i'm missing something?
i mean, it's all linked in various ways depending on the individual right. and even thin cysters, or cysters who have lost weight .. might age and still continue to struggle with hormone/insulin control depending on various factors, which might in turn lead to eventual elevated risk for DM. so it seems to me that saying, one does not affect the other unless you are obese/have metabolic alterations is a slightly blurred assessment. again, i could just be interpreting this the wrong way.
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but isn't this like saying 'you aren't at increased risk for diabetes unless you have IR/weight issues.. yet you have IR/weight issues because of PCOS so ... ' it just doesn't seem like a profound statement, unless i'm missing something?
I haven't read the full study, so my guess that follows is related to only the abstract.
In the past is was suggested that ALL women with PCOS were at a higher risk of developing Type II diabetes.
The study seems to suggest that this may not be the case. That in women PCOS the only ones with increased risk of Type II diabetes are those PCOS'ers who also have obesity and/or metabolic alterations.
(I could be wrong, but that's what I'm taking from it.)(Also, this was a small study..so take it with a grain of salt)
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Are All PCOSers At Risk for Diabetes? Study Says, "No" 
