Hi Nicole! I take 500 mg of Met two times per day, plus 100 mg of Zoloft one time per day. I have not experienced any side effects that I am aware of, but I never take them at the same time. I take my Met with breakfast and with dinner, and my Zoloft with lunch. I don't know if that makes a difference or not, but I just feel better doing it that way. Last night I forgot to take my vitamins in the afternoon, so I figured I would just take them with my dinner and my evening Met, and sure enough, I woke up in the middle of the night with an upset tummy. So, I always figure the less my tummy has to process at once, the better!
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