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Old 05-09-2009, 07:07 PM   #1 (permalink)
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Has anyone else had her anti-Mullerian hormone (AMH) level tested? Does a low value definitely preclude the possibility of PCOS? Also, when you were diagnosed with polycystic ovaries, were you told how many follicles you had?

Recently, a fertility specialist ran tests to confirm suspected PCOS. Much to my surprise, when I returned for the results, the doctor said he was ruling out a PCOS diagnosis because my AMH was low – so low, in fact, that it put in the ‘low fertility’ group. In addition, he said my ovaries technically didn’t qualify as polycystic because I only had six follicles, and the clinical definition requires at least 12.

I’ve had three ultrasounds before and each time told my ovaries were polycystic – but doctors never gave a follicle count. Is it possible my ovaries have improved, or could they have been using different criteria? Could the fact that I'd recently taken four cycles of Clomid have affected the follicle count?

If I don't have PCOS, what else could explain the elevated LH reading I had a year ago? It was done mid-cycle, so it wasn't as accurate as a day-3 reading, but my ratio was 3:1 – isn't that indicative of PCOS even if the test was done on the wrong day?


Background:

For the past three years, doctors not been able to agree on a diagnosis to explain my amenorrhea and infertility. I was told I have polycystic ovaries but 'most likely' did not have PCOS because of my low hormone levels (androgens and estrogen) and body weight. I was told to gain weight. I managed to gain 5 pounds, and my periods returned, by I was still very irregular and unable to conceive. Finally, I had an elevated LH reading, and my doctor referred me to a fertility specialist.

Many thanks for any advice you can offer!
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Old 05-10-2009, 08:29 PM   #2 (permalink)
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I just recently had my AMH tested and it came back at 8.2. My dr. didn't say much about the result but I have found through online articles and such that higher numbers, i.e. anything over 5 is supposed to be indicitive of PCOS. Did your Dr. tell you your number?

I already knew I had PCOS based on high testosterone and high LH, so this wasn't news to me or my Dr. I think that's why he didn't discuss the result with me. I know I have a high number of follicles also, but he didn't tell me how many.

From what I've read online, AMH is a fairly new test. Have you had the day 3 FSH test done? I would think the Dr. would want to do that test also if he's concerned about your AMH result.
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Old 05-11-2009, 08:17 PM   #3 (permalink)
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Hi there. Many thanks for your reply. My AMH level was 12 pmol/L -- not sure of the conversion factor into US measurements, but it puts me in the 'low fertility group' (in international units, anything above 48 suggests PCOS, and anything between 2-15 is low). My doctor said that it's not a problem as my FSH is good and I'm closer to the top end of the 'low fertility' range, but he didn't really explain the signifiance beyond that. I would think the two would correlate -- don't understand how one can be good and the other, well, not so good. And as you say, it's a relatively new test, so I can't find much information on it. Thanks again for your help -- I'm hoping to learn more from my doctor on y next appointment.
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Old 05-11-2009, 08:35 PM   #4 (permalink)
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Oh, OK I didn't even think about the measurement . . . . mine was in ng/ml, and I have no idea how to convert either. But if your FSH is fine then I would think you are OK. My gyne only tested my FSH and said I was fine based on that. Its the new RE I'm seeing who did the AMH along with the FSH. He didn't even explain the AMH results to me, but he did go into detail about the FSH. So I don't know how much stock they are putting in AMH anyway. I had never even heard of the test until his nurse was drawing the blood! Anyway, hope that helps and good luck!
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