 Anti-oxidant instead of Metformin? (article)
Antioxidant may improve PCOS insulin profiles
Source:
Fertility and Sterility 2002; 77: 1128-35
An antioxidant drug is proposed as a potential new treatment for improving insulin sensitivity in certain polycystic ovary syndrome patients.
An antioxidant drug could provide a novel treatment for hyperinsulinemic women with polycystic ovary syndrome (PCOS), suggest study findings. N-Acetyl-cysteine (NAC), commonly used as a mycolytic drug, was shown to improve circulating insulin levels, and insulin sensitivity in such women.
A team from Universitá del Sacro Cuore in Rome, Italy, studied 37 women with PCOS, aged 19-33 years. Women with impaired glucose tolerance or diabetes were excluded from the study. Thirty-one of the participants (six lean, 25 obese) were treated with oral NAC at a dose of 1.8 g/day for 5-6 weeks. Six control subjects (all obese) received placebo.
After treatment, insulin area under curve, a measure of insulinemic response to an oral glucose tolerance test, was significantly reduced, and insulin sensitivity increased, report lead researcher Dr. Antonio Lanzone and colleagues. Further analysis revealed that these parameters were only improved in hyperinsulinemic subjects treated with NAC, and not in normoinsulinemic or placebo-treated patients.
"The preliminary results on the effectiveness of the antioxidant drug NAC suggest that it may be a new treatment for hyperinsulinemia in patients with PCOS, which is of note also because of the absence of side effects," conclude the researchers.
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Robin
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