smk

Hi All -

I was diagnosed with PCOS about a month ago. I have been taking glucophage XR for 2 weeks now (I took regular, generic metformin for one week - 500 mg.) I switched to XR because it is easier to take. I am supposed to increase it to 1000 mg tonight and eventually go up to 1500 mg.

I have also been taking imiprimine 50 mg. (a tricyclic antidepressant) for about 5 years now for anxiety (and migraines). I have felt great on the imiprimine with occasional bouts of anxiety here and there. For the past two days I have had some anxiety and sort of the doldrums. I'm wondering if it could be PMS? Last month I started AF around January 3, but I was taking my provera (10 mg.) I decided not to take the provers this month just to see how things go. I feel like AF could be coming, so maybe that's why I have the anxiety and doldrums?

Could it be that my hormones are just really out of whack right now? I'm worried that the glucophage XR is causing the imiprimine to not work. Or could the gluc be causing anxiety?

It sounds silly I know, but I tend to worry about these things!

Has anyone else has a similar experience? Thanks in advance!

__________________
Age:28
Engaged – wedding is 10/18/2003!
Not TTC
Menstruating since age 11 and it has been irregular ever since!
Taking provera 10 mg for 10 days/month since high school
Finally diagnosed with PCOS November 2002
Started Glucophage January 17, 2003 (500 mg. and working my way up to 1500 mg.)
My list of meds: provera 10 mg. (ten days/month); levoxyl 50mg. for thyroid goiter; imiprimine 50mg. for anxiety; glucophage XR
PCOS symptoms: weight gain; difficulty losing weight; very oily skin; bouts of acne; excess hair on chin; irregular periods
Vitamin Supplements: multivitamin; magnesium & calcium; B-complex; chromium (glucose tolerant factor)

taah

I wish i had some answers for you but I haven't had that problem..... the met i am on hasn't caused my anxiety to be any worse or anything...... i am on zoloft and it seems to be still working.......... i wish i could offer more help....... you may want to check in the Met forum and see if they could help......... also talk to your docs about it and see if they have any info that can help..

Good luck............


TERRA

__________________
me 30 hubby 34
PCOS, IR
Metformin 2000mg

TTC#1
5 m/c

santa'sbaby

I just wondered if perhaps it may be in relation to your blood sugar levels.

I was out about 2 weeks ago, I had gone to the movies with my fiance. I didn't eat anything during the day and I took my meds. I ate popcorn at the movie theatre and we had icecream about 20 mins later. Then about 20 mins after the icecream, my stomach went into a cramp, I got lightheaded, my heart pounded and I went all clammy. I felt ill. I know now that I overloaded on Carbs and then my sugar level dropped and knocked me on my ass. Low blood sugar levels can also make you cry at the drop of a hat!

When you are taking meds, you have to keep that protein/carb thing balanced.

I don't know if this helps or not.

Let us know!

__________________
Me 35, DH 52. DSS 22, DD 15
150mg of Effexor
Hysterectomy on Jan 17, 2006
Going back on Meds June 1st to treat PCOS symptoms though ovaries are gone.
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smk

Thank you both very much!

I just got off the phone with one of the nurses at my doctor's office and she is going to have the doctor call me back. She thought maybe the XR is causing the problem and advised that I take the regular metformin I was initially given, but I'll know more once the doctor calls me back.

I'm also wondering if the thyroid medicine (levoxyl) is causing the problem because I've read that metformin can have some sort of interaction with thyroid medicine.

I'll keep you posted!
Thanks again!!
Sara : )

__________________
Age:28
Engaged – wedding is 10/18/2003!
Not TTC
Menstruating since age 11 and it has been irregular ever since!
Taking provera 10 mg for 10 days/month since high school
Finally diagnosed with PCOS November 2002
Started Glucophage January 17, 2003 (500 mg. and working my way up to 1500 mg.)
My list of meds: provera 10 mg. (ten days/month); levoxyl 50mg. for thyroid goiter; imiprimine 50mg. for anxiety; glucophage XR
PCOS symptoms: weight gain; difficulty losing weight; very oily skin; bouts of acne; excess hair on chin; irregular periods
Vitamin Supplements: multivitamin; magnesium & calcium; B-complex; chromium (glucose tolerant factor)