hmmmmm, i ahve just read that taking taurine on a low carb diet can help you lose weight. has anyone heard this or tryed it? thank you!
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__________________ dx pcos 1984, type II diabetes 2001, also hypertension
Met 2000mg since 2001, started Glucophage XR 4/22/04, then switched to Met ER 6/04; also: multi, Vit. C, Vit. E, B12/folic acid combo, fish oil & borage oil combo, garlic capsules, cinnamon, Vitex, calcium with magnesium/zinc, biotin, CoQ10, selenium,iron
Other meds: Verapamil and Altace(for blood pressure)
Started laser hair removal 7/29/03, completed 3/04 (it works!)
UAE for fibroid 3/24/03 and 3/16/04
Here are the references (in no particular order) for the information I list about Taurine on my web page. There are quite a few brand new studies too, as I just found. For the most part, it appears to do some pretty good stuff related to insulin sensitivity, diabetes and diabetes related biochemical features. So, there is little doubt it would have at least some benefit in PCOS. Too bad there are no studies yet on Taurine and PCOS specifically.
There is one recent disappointing study on Taurine, listed below, at the bottom. The 1.5 grams/day used in the study is very low for an amino acid dose. A dose 3-4 times that would have been more realistic. Some of the animal studies below used the equivalent human dose of 20 grams/day of Taurine (I'm not suggesting 20 grams is a good idea -- they often go overboard in the animal studies). But, still, you would have hoped they found increased insulin sensitivity. If it was a good study (no guarantee), and if Taurine is capable of increasing insulin sensitivity in humans (which other studies suggest), then the conclusion may be that if you're going to take it, you need more than 1.5 grams/day or you're wasting your time.
Taurine increases glucose sensitivity of UCP2-overexpressing {beta}-cells by ameliorating mitochondrial metabolism. Am J Physiol Endocrinol Metab. 2004 Jul 20 [Epub ahead of print]
Taurine alters respiratory gas exchange and nutrient metabolism in type 2 diabetic rats. Obes Res. 2004 Jul;12(7):1077-84.
Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids. 2004 Jun;26(3):267-71. Epub 2003 Dec 15.
[Study of teratogenicity of hyperglycemia on neural tube defects and antagonistic effect of taurine] Zhonghua Fu Chan Ke Za Zhi. 2004 Mar;39(3):169-72. Chinese.
N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E744-53. Epub 2003 Jun 10.
Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance. Can J Physiol Pharmacol. 1999 Oct;77(10):749-54.
Insulin resistance: lifestyle and nutritional interventions. Altern Med Rev. 2000 Apr;5(2):109-32.
Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes. Am J Clin Nutr. 2000 Jan;71(1):54-8.
Taurine protects against oxidant-induced lung injury: possible mechanism(s) of action. Adv Exp Med Biol. 1994;359:31-9.
Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor in activated RAW 264.7 cells. J Leukoc Biol. 1993 Aug;54(2):119-24.
Taurine chloramine down-regulates the generation of murine neutrophil inflammatory mediators. Immunopharmacology. 1998 Jul;40(1):27-38.
Taurine chloramine inhibits inducible nitric oxide synthase and TNF-alpha gene expression in activated alveolar macrophages: decreased NF-kappaB activation and IkappaB kinase activity. J Immunol. 2001 Aug 15;167(4):2275-81.
Taurine reduces mortality in diabetic rats: taurine and experimental diabetes mellitus. Adv Exp Med Biol. 2003;526:67-73.
Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S250-3.
Taurine levels in plasma and platelets in insulin-dependent and non-insulin-dependent diabetes mellitus:correlation with platelet aggregation. Adv Exp Med Biol 1994;359:419-424.
Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus:effects of taurine supplementation. Am J Clin Nutr 1995;61:1115-1119.
Taurine and diabetes. Humans and experimental models. Adv Exp Med Biol 1996;403:579-582.
First experiments in taurine administration for diabetes mellitus. The effect on erythrocyte membranes. Adv Exp Med Biol 1996;403:583-588.
Restoration of endothelium-dependent relaxation in both hypercholesterolemia and diabetes by chronic taurine. Eur J Pharmacol 1996;303:47-53.
The role of taurine in the pathogenesis of the cardiomyopathy of insulin-dependent diabetes mellitus. Cardiovasc Res 2000;46:393-402.
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Eur J Clin Nutr. 2004 Sep;58(9):1239-47.
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Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus.
Brons C, Spohr C, Storgaard H, Dyerberg J, Vaag A.
BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) is increasing with an epidemic growth rate. Animal studies with taurine supplementation have shown increased insulin secretion and action, suggesting that taurine supplementation may have a potential to prevent T2DM. OBJECTIVE: To assess the effect of taurine treatment on insulin secretion and action, and on plasma lipid levels in overweight men with a positive history of T2DM. DESIGN: 20 nondiabetic subjects were included in a double-blinded, randomized, crossover study, receiving a daily supplementation of 1.5 g taurine or placebo for two periods of 8 weeks. The subjects were overweight first-degree relatives of T2DM patients. An intravenous glucose tolerance test (IVGTT) was used to measure first-phase insulin secretory response, and a euglycemic hyperinsulinemic clamp was used to determine peripheral insulin action. RESULTS: Mean plasma taurine concentration was 39 +/- 7 (s.d.) micromol/l after placebo and 131 +/- 62 micromol/l after taurine intervention (P < 0.0001). There was no significant difference after taurine intervention compared to placebo in incremental insulin response (Insincr.) neither during the IVGTT, nor in insulin-stimulated glucose disposal during the clamp. Insulin secretion, adjusted for insulin sensitivity, was also unchanged. There was no significant effect of taurine supplementation on blood lipid levels as well. CONCLUSION: Daily supplementation with 1.5 g taurine for 8 weeks had no effect on insulin secretion or sensitivity, or on blood lipid levels. These findings in persons with an increased risk of T2DM are in contrast to those from animal studies, and do not support the assumption that dietary supplementation with taurine can be used to prevent the development of T2DM.
__________________ My PCOS treatment research summary:
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Before I went on holiday I decided to try tuarine - I physically can't take any vitamine etc. in supplement form so I started having a sugar free red bull each day.
Now I am back and getting back into my diet and exercise routine I'm going to add it in again. I am a very slow loser int he fat department but I am trying it to see if it makes any difference.
I haven't had enough time to tell yet though
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Got to wean myself off that carb overload I've been having lately...... To view links or images in signatures your post count must be 0 or greater. You currently have 0 posts.
any one ever heard or tried taurine? 
