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Symptoms of Premenstrual dysphoric disorder?

Posted 05-14-2009 at 07:31 AM by Auspice
Do you have 5 or more Symptoms...
It may indicate PMDD. Symptoms occur during the week before the menstrual cycle and disappear within a few days after the onset of the bleeding.

PMDD is premenstrual syndrome (PMS) that is so severe it can be debilitating due to either physical, mental or emotional symptoms. Treatment is recommended because PMDD interferes with the sufferer's ability to function in her social or occupational life.

The cardinal symptom--surfacing between ovulation and menstruation, and disappearing within a few days after the onset of the bleeding--is irritability (PMID 11571794). Anxiety, anger, and depression may also occur. The main symptoms, which can be disabling, include[3]
  • feelings of deep sadness or despair, possible suicide ideation
  • feelings of tension or anxiety
  • panic attacks
  • diarrhea
  • mood swings, crying,
  • lasting irritability or anger, increased interpersonal conflicts
  • apathy or disinterest in daily activities and relationships, yeast infections
  • difficulty concentrating
  • fatigue
  • food cravings or binge eating
  • insomnia or hypersomnia
  • feeling "out of control",
  • increase or decrease in sex drive.
  • increased need for emotional closeness,
  • physical symptoms: bloating, heart palpitations, breast tenderness, headaches, joint or muscle pain, swollen face

Genetic links

...women with PMDD have an abnormal response to normal hormone levels, and, thus, are differentially sensitive to their own hormone changes. In a study, Dr. Liang Huo and colleagues, found variants in the estrogen receptor alpha gene. Only seen in women with a variant form of another gene, catechol -- o -- methyltransferase (COMT), which is involved in regulating the function of the prefrontal cortex, a critical regulator of mood.

Originally called late luteal phase dysphoric disorder (LLPDD), the disorder was renamed PMDD by the American Psychiatric Association.

While the cause of PMDD has not been definitively established, a leading theory suggests it is due to the lack of serotonin (a neurotransmitter) and mediated by the fluctuations of the levels of sex hormones (progesterone, estrogen, and testosterone) in the luteal phase of the menstrual cycle.

The most effective is Yaz and Yazmine. SSRI's to treat the mood component. Progesterone should not be used, is shown to be at the root of PMDD.

More info at http://en.wikipedia.org/wiki/PMDDhttp://
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