Calcium - A Cure All?

GetnCrzyWChzWiz · 09-22-2005, 04:06 PM

In my quest to blame something for my massive hair loss, I've been doing some internet research. Hope some of you can find this stuff useful!!

Calcium - a cure all?

http://www.umm.edu/altmed/ConsSupplements/Calciumcs.html

Metformin and HBP meds are mentioned in this article.

http://www.ovarian-cysts-pcos.com/multi-description.html

"Calcium appears to improve insulin sensitivity....."

http://www.pharmacy.wsu.edu/courses/PharP542/GroupB_Antidiabetic%20nutrient%20depletion.doc

Depleted Nutrients by Antidiabetic Medications

Sulfonylureas Coenzyme Q₁₀¹

Acetohexamide (Dymelor®)Congestive heart failure, high

Chloropropamide (Apo®-Chorpropamide; blood pressure, angina, mitral

Apo®-Propamide) valve prolapse, stroke, cardiac

Glimepiride (Amaryl®) arrhythmias, cardiomyopathy, lack

Glipizide (Glucotrol®; Glucotrol-XL®) of energy, gingivitis, and generalized

Glyburide (Micronase®, Glynase™, weakening of the immune system

DiaBeta®, PresTab™)

Glyburide and Metformin (Glucovance™)

Tolazamide (Tolinase®)

Tolbutamide (Apo®-Tolbutamide,

Mobenol®, Novo-Butamide)

Meglitinides

Repaglinide (Prandin™)

Biguanides Folic acid²

Metformin (Glucophage®) Megaloblastic anemia, birth defects,

Glyburide and Metformin (Glucovance™) cervical dysplasia, elevated

homocysteine, headache, fatigue,

hair loss, anorexia, insomnia,

diarrhea, nausea, and increased

infections

Biguanides Vitamin B₁₂^{2 3 4 5 6}

Metformin (Glucophage®)Fatigue, peripheral neuropathy,

Glyburide and Metformin (Glucovance™) tongue and mouth irregularities,

macrocytic anemia (abnormally

enlarged red blood cells), depression,

confusion and memory loss

(especially in the elderly), poor

blood clotting and easy bruising,

dermatitis and skin sensitivity, loss

of appetite, nausea, vomiting

Sources/Recommended Doses

Coenzyme Q₁₀_:30-100mg. Some have reports of benefits for certain health

conditions (e.g., severe cardiovascular disease and advanced breast cancer) with dosages of 300-360mg/day. Although coenzyme Q₁₀compounds are found in cells of all plants, animals, and plants, the level of coenzyme Q₁₀ from our diet is believed to be inadequate to meet our needs.

Folic acid: 200-800mcg/day. For severely deficient patients: 5000-10,000mcg/day.

Dark green leafy vegetables, brewer’s yeast, liver, eggs, beets, broccoli, brussels sprouts, orange juice, cabbage, cauliflower, cantaloupe, kidney and lima beans, wheat germ, whole grain cereals and breads. Folic acid is synthesized by the “friendly” intestinal bacteria.

Vitamin B₁₂: 100-2000mcg/day. Produced by microbial synthesis in the digestive tract

of animals. Organ meats, clams, oysters, beef, eggs, milk, chicken, and

cheese. Oral supplements are not well absorbed. Intramuscular injection is

the most effective route of administration, especially for the elderly.

Contraindications/Precautions:

Coenzyme Q₁₀: Contraindicated in pregnant and breast-feeding women. Patients with

diabetes need to monitor blood sugar carefully because coenzyme Q₁₀ may decrease glucose levels. Patients taking warfarin should have their protimes monitored carefully. Coenzyme Q₁₀ should not be stopped suddenly, as it may worsen symptoms of heart failure.Patients who are alcohol dependence, have liver disease, or allergies should talk to their doctors before taking Coenzyme Q_10.

Folic acid: Pernicious, aplastic, or normocytic anemias. Doses >0.1mg/day may obscure

pernicious anemia with continuing irreversible nerve damage progression. Resistance may occur with depressed hematopoiesis, alcoholism, deficiencies of other vitamins. Injection containing benzyl alcohol (1.5%) as preservative (use with care in administration to neonates).

Vitamin B₁₂: Hypersensitivity to cyanocobalamin or any component, cobalt; patients with hereditary optic

nerve atrophy. Take precautions when using I.M. route used to treat pernicious anemia; vitamin B12 deficiency >3 months results in irreversible degenerative CNS lesions; treatment of vitamin B12 megaloblastic anemia may result in severe hypokalemia, sometimes, fatal, when anemia corrects due to cellular potassium requirements. B12 deficiency masks signs of polycythemia vera; vegetarian diets may result in B12 deficiency; pernicious anemia occurs more often in gastric carcinoma than in general population.

Reference

1. Kishi T, Kishi H, Watanabe T, et al. “Bioenergetics in Clinical Medicine. XI.

Studies on Coenzyme Q and Diabetes Mellitus.” J Med 1976, 7(3-4): 307-21.

2. Carlsen SM, Folling I, Grill V, et al. “Metformin Increases Total Serum

Homocysteine Levels in Nondiabetic Male Patients With Coronary Heart Disease.” Scand J Clin Lab Invest 1997, 57(6): 521-7.

3. Adams JF, Clark JS, Ireland JT, et al. “Malabsorption of Vitamin B12 and Intrinsic

Factor Secretion During Biguanide Therapy.” Diabetologia 1983, 24(1): 16-8.

4. Carpentier JL, Bury J, Luykx A, et al. “Vitamin B12 and Folic Acid Serum Levels in

Diabetics Under Various Therapeutic Regimens.” Diabete Metab 1976, 2(4): 187-90.

5. Berger W. “Incidence of Severe Side Effects During Therapy With Sulfonylureas

and Biguanides.” Horm Metab Res Suppl 1985 15: 111-5.

6. Berchtold P, Bolli P, Arbenz U, et al. “Disturbance of Intestinal Absorption

Following Metformin Therapy (Observations on the Mode of Action of

Biguanides).” Diabetologia 1969, 5(6): 405-12.

7. “Coenzyme Q10.” Encyclopedia of Health Concerns and Individual Nutrients. 2002. Internet. 5

April 2002. Available: www.vitacost.com/science/nutrients/coenzymeq10.html.

8. “Coenzyme Q10 Oral Precautions”. Medscape Drug Info. Windows Version. New York (NY):

Medscape Portals, Inc.: 1994-2002.

9. Lacy, CF, Armstrong LL, Morton PG, et al. Drug Information Handbook. 8^th ed. Hudson: Lexi-

Comp, Inc., 2000-2001.

10. Pelton, R, LaValle JB, Hawkins EB, et al. Drug Induced Nutrient Depletion Handbook. 2^nd ed.

Hudson: Lexi-Comp, Inc., 2001.