clomid administration

slimcys · 03-09-2005, 05:26 PM

I have a question. I have been prescribed clomid alone. I have very few PCOS symptoms other than the irregular cycles. I was prescribed 50 mg at first with no ovulation and now am on 100 mg. My question is, I have read that taking clomid from day 3 instead of day 5 results in higher pregnancy rates due to the decrease anti-estrogenic side effects but can potentially mean less percentage of it working. That is, you are less likely to ovulate taking it day 3 but if you do, you'll have a higher chance of conceiving. I took it day 3 the first round with no ovulation. Just wondering if I should switch to day 5. My doctor just suggested day 5 because it is the standard. Anyone have any insights on what day to take it or have heard of anything?

lissadell · 03-10-2005, 06:35 PM

Hi,

I have heard that taking Clomid from CD3-CD7 can result in more follices and taking it from CD5-CD9 can result in fewer, but more mature follicles. It's not 100% proven though, and varies a lot from woman to woman. My RE said he personally hasn't seen much of a difference in success rates between women who take the meds on different days.

I took 50mgs of Clomid from CD5-CD9 for three cycles - ovulated each time and got my BFP on the third try. I was being monitored by my RE and had a trigger shot to induce ovulation. BTW, I had one mature follie the first cycle and two the last two cycles.

Are you being monitored at all? It may be worth looking into since sometimes you can produce mature follies, just not ovulate - which is why the trigger is helpful.

Switching to day 5 might help you too, since you may produce mature follies.

Hope this helps. Much luck & babydust!

slimcys · 03-11-2005, 12:23 PM

Thanx for your input. I'm being followed my a gynecologist right now and he does not have the facility to do ultrasound to follow me. I know it's a waste. However, we're just trying this round until I get into a fertility clinic in April to see a RE. I will definitely be followed then which I'm hoping I won't need. We'll see. I'll try taking the clomid CD 5 this time. What's in the trigger shot?

saluki_fan · 03-11-2005, 12:29 PM

Quote:

I have heard that taking Clomid from CD3-CD7 can result in more follices and taking it from CD5-CD9 can result in fewer, but more mature follicles. It's not 100% proven though, and varies a lot from woman to woman. My RE said he personally hasn't seen much of a difference in success rates between women who take the meds on different days.

I have heard the above as well. My first OB preferred Days 5-9, and my new OB and the RE I consulted with both prefer Days 3-7 because of getting more follicles.

I've tried it both ways and gotten PG on both Days 5-9 and 3-7. I am also a "thin" cyster - 5'5' and about 125 pounds - and the only symptom I have is irregular cycles. Once I started taking Metformin, my cycles became regular and ovulatory. Each time I got PG on Clomid, I was also taking Metformin.

Hope this helps...

slimcys · 03-11-2005, 01:14 PM

I was always wondering about taking metformin without getting the lab values indicating IR. My doctor didn't think I needed metformin since my lab values showed no IR and I never had a weight problem but I read that it works for those without IR also. What was your doctor's reasoning behind prescribing it to you?

saluki_fan · 03-11-2005, 01:20 PM

I don't know if my doctor had any reasoning behind prescribing it -she never bothered to run the IR test on me! But it worked the first month, and every other month after when combined with Clomid! Also, during the 3 months when we couldn't TTC, I continued to chart. All those cycles were ovulatory and ranged from 27 to 35 days. So even if I am NOT IR, I'd like to stay on Metformin. My new doctor has agreed to that.