DCI - D-Chiro-Inositol and WOW!!! - Page 13

moredd · 07-25-2009, 03:10 AM

I asked Chiralbalance about upping my dose... got an answer back of not at this time.

Havent been seeing the weight loss I've wanted the last few days even though I suspect its AF getting ready to show so I asked.

JenSlayton · 07-25-2009, 09:30 AM

So after reading about the dosage recomendations for DCI I realized that my weight-dependent dose for DCI would be twice the recommended dose, so I went ahead and increased it...

For most of this cycle I have been taking the two capsules I was taking before in the morning (with a glass of water 30 minutes before breakfast, as recommended), and then added two in the evening before dinner for a total of 2400mg.

I am now where I should probably be pms-ey (my cycles are variable so I could be off a few days... week... who knows?) and am having a SUPER breakout!!! It is awful, my whole chin has acne, which I almost never have (maybe one zit before my period max, and now it is like 10).

After reading the posts I am wondering if this could be the DCI? I never had this much acne before (except maybe as a teenager), but I was apparently taking about half the dose that would be recommended for my size, so could this be a sign that I am now taking a sufficient amount?

Any thoughts or anyone else have this experience?

VVildflames · 07-25-2009, 05:12 PM

Has anyone taken DCI while also taking metformin or spirolactone?

If so any affects on your Insulin resistance? AKA hypoglycemia reactions? Did it help with mental clarity?

VVildflames · 07-25-2009, 05:27 PM

Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome

John E. Nestler, M.D., Daniela J. Jakubowicz, M.D., Paula Reamer, M.A., Ronald D. Gunn, M.S., and Geoffrey Allan, Ph.D.

Background Women with the polycystic ovary syndrome have insulinresistance and hyperinsulinemia, possibly because of a deficiencyof a d-chiro-inositol–containing phosphoglycan that mediatesthe action of insulin. We hypothesized that the administrationof d-chiro-inositol would replenish stores of the mediator andimprove insulin sensitivity.
Methods We measured steroids in serum and performed oral glucose-tolerancetests before and after the oral administration of 1200 mg ofd-chiro-inositol or placebo once daily for six to eight weeksin 44 obese women with the polycystic ovary syndrome. The serumprogesterone concentration was measured weekly to monitor forovulation.
Results In the 22 women given d-chiro-inositol, the mean (±SD)area under the plasma insulin curve after the oral administrationof glucose decreased from 13,417±11,572 to 5158±6714µU per milliliter per minute (81±69 to 31±40nmol per liter per minute) (P=0.007; P=0.07 for the comparisonof this change with the change in the placebo group); glucosetolerance did not change significantly. The serum free testosteroneconcentration in these 22 women decreased from 1.1±0.8to 0.5±0.5 ng per deciliter (38±28 to 17±17pmol per liter) (P=0.006 for the comparison with the changein the placebo group). The women's diastolic and systolic bloodpressure decreased by 4 mm Hg (P<0.001 and P=0.05, respectively,for the comparisons with the changes in the placebo group),and their plasma triglyceride concentrations decreased from184±88 to 110±61 mg per deciliter (2.1±0.2to 1.2±0.1 mmol per liter) (P=0.002 for the comparisonwith the change in the placebo group). None of these variableschanged appreciably in the placebo group. Nineteen of the 22women who received d-chiro-inositol ovulated, as compared with6 of the 22 women in the placebo group (P<0.001).Conclusions d-Chiro-inositol increases the action of insulinin patients with the polycystic ovary syndrome, thereby improvingovulatory function and decreasing serum androgen concentrations,blood pressure, and plasma triglyceride concentrations.

VVildflames · 07-25-2009, 06:03 PM

Altered D-Chiro-Inositol Urinary Clearance in Women With Polycystic Ovary Syndrome

Abstract

OBJECTIVE—Evidence suggests that some actions of insulin are effected by inositolphosphoglycan (IPG) mediators. We hypothesize that a deficiency in D-chiro-inositol (DCI) and/or a DCI-containing IPG (DCI-IPG) may contribute to insulin resistance in humans.
RESEARCH DESIGN AND METHODS—To assess this possibility in polycystic ovary syndrome (PCOS), we determined insulin sensitivity (Si by frequently sampled intravenous glucose tolerance test), plasma and urinary DCI and myo-inositol (MYO) levels (by gas chromatography/mass spectrometry), and the release of insulin and DCI-IPG during the oral glucose tolerance test (area under the curve [AUC]) in 23 women with PCOS and 26 normal women.
RESULTS—Women with PCOS were heavier than control subjects (P = 0.002 for BMI), but also had decreased Si (P < 0.001) and increased AUCinsulin (P < 0.001) compared with normal women, even when corrected for BMI. The urinary clearance of DCI (uClDCI) was increased almost sixfold in PCOS compared with normal women (P = 0.001), but not MYO clearance (P = 0.10). uClDCI correlated inversely with Si when all women were analyzed together (n = 49, r = −0.50, P < 0.001) and was one of the three best independent parameters predicting Si. Finally, the ratio of AUCDCI-IPG to AUCinsulin was decreased threefold in women with PCOS (P < 0.001).
CONCLUSIONS—uClDCI is inversely correlated with insulin sensitivity in women and is a strong independent predictor of insulin resistance in multivariate models. PCOS, which is characterized by insulin resistance, is associated with a selective increase in uClDCI and impaired DCI-IPG release in response to insulin. These findings are consistent with a defect in tissue availability or utilization of DCI in PCOS that may contribute to the insulin resistance of the syndrome.

moredd · 07-26-2009, 02:46 AM

I am taking DCI and Met, no issues, one of my earlier posts says Spironolactone may not be the best mix with DCI however my Dr said to go ahead and take both because i need to get my andogen levels down.

Shoshi29 · 07-26-2009, 11:55 AM

moredd: I know you have been trying the low carb diet. I have been on the ultra-metabolism diet for a little over 2 months. It works really great to detox your system. I would definitely recommend the cookbook! I looked at the insulin resistance diet book (read book but didn't buy) and also ordered 1 month of the insulite pcos system because it has a diet and exercise plan ($99). I was surprised to learn a lot of the foods in the traditional low carb diet are not good for you pcos-wise. For example, grapes, mangoes and papaya are to be avoided. There are a lot of other surprising foods which I haven't avoided but will now. I know its expensive, but if you get the starter kit I think the diet plan and exercise regimen alone are worth it.

ciadmilefailte: Have you tried ovation cell therapy? Its a shampoo, cell therapy treatment and creme rinse that you use in shower or leave on overnight for deep treatment. I know it made my hair thicker.

moredd · 07-27-2009, 02:29 AM

grapes, mangoes and papaya are all mid to high carb foods and are craving triggers for me, have always avoided them as much as possible.

I found out today that I need to actually UP my caloric intake... have not been craving carbs, food etc and had realized for the last week id been eating 900 or less calories per day. I actually in order to continue to loose weight need to go to 1200-1500. lol

Reags · 07-27-2009, 02:39 AM

So the acne seems to be dying down - which is good - I have tried a low carb things and I don't loose anything - I lost 48lbs in a year, but now I just sit I gain a little then work hard to take it off. With this DCI it has helped my weight and I still don't crave eating - I had been taking the DCI for two months at night before bed - tomorrow I start my third month and I will take it in the morning - I hope that I will see even more of a change - as anyone else done the Beet juice - This has also made a difference.

Reags · 07-27-2009, 02:41 AM

moredd - I agree with the caloric intake - I have also noticed that I have to remind myself to eat- crazy because before the DCI it was like I just ate and I need to eat again - I was always hungry

moredd · 07-27-2009, 02:38 PM

Well the good news is that after increasing to a proper caloric intake my weight loss immediatly started again the next day. What crazy bodies we have lol

doesitinspire · 07-27-2009, 03:56 PM

This thread has been really hopeful. I'm seeing a new endocrinologist in two weeks. Think I should wait until after seeing him to start?

herbsgirl · 07-27-2009, 05:01 PM

Wow, what alot of posts scince Ive been on vacation. I stopped the cinnamon for now, and sure enough, the signs of ovulation came back. I have been on DCI now for over 3 weeks, I am in my 4th week of taking it.

My acne has almost disappeard pretty much, except one close to my nose.

My skin maybe just looks more clear, smooth, more beautiful or something, mabye its helping my pores??

The dark hairs on my chin are not growing back very fast so far??! The DCI is definatly doing something to my body.

Another thing I have noticed with the DCI, its a TMI!!! I have been wanting S*X much more, and its more fun!

I upped my dose to 1800 mg per day, which would be around the 20 mg per kg of body weight dosage guidelines, and I have been on that higher dose for a few days.

Just waiting for the ovulation to come!

krisskross · 07-27-2009, 07:24 PM

I have also upped my dose to 1800 mg. I have notice that my bbt is less erratic now. I assume that it a good sign.

How would I go about finding out my caloric intake needed to lose weight?

moredd · 07-27-2009, 08:43 PM

My Dr said 1200-1800 cal/day
Another website said 3000 (for my hieght and weight)
Im going to do what my Dr says *grin*

Herbsgirl on the TMI part: ME TOO!!! its awesome

, also any ideas on why the lack of cinnamon is making the difference in O signs? Any research backing this up? I had signs I thought of Oing and have not seen AF yet but am not preg either.

doesitinspire: I would get your baseline bloodwork done before you go on it if you can, however most endos dont seem to think much of natural remedies. Ask him if you can take it but if he doesnt know what it is just take the Dr's pamplet from www.chiralbalance.com for him to look at at least. Explain its a naturally occuring vitamin and see if he is ok with you taking it. Also have your testosterone levels checked because DCI will lower them and you are already on Spiro for that. If you take it make sure you have your levels monitored to make sure that they don't go to low (although that would be pretty low).

Another interesting note: I had a glucose tolerence test today (12 hour fast, 75g of glucose, blood draws at 0, 1 hr and 2 hrs) 30 minutes after I had the glucose my ankles and fingers swelled somewhat (this had gone away when i cut my carbs and started the DCI), my joints and muscles started aching and I got fuzzy headed and extrememly tired and shaky and got a low-grade headache. I also felt lethargic and heavy and like I had no energy. All of these were pre-DCI & low carb symptoms and they hit with a vengance with the glucose dose. (they had me lie down for the rest of the time I was there) Anyone else ever had this happen?