decreased response with increased clomid dosage?

suki_jones · 06-27-2009, 04:07 AM

Hello,
I just had my second round of clomid, and after a somewhat positive first round (18mm follicle, only 1 but it was good!) of 50mg, the Dr. was disappointed to see the increased dosage (100mg) produced a weak candidate on the right (which actually shrank as we monitored the ultrasounds) and the one of the left only got to 17mm after an extra week of growth. I self-injected the next day with the meds to induce follicle release and kept with the "prescribed regimen" for the next 4 days with my hubby.

Now, we wait. The Dr. has said that we might go with 150mg of clomid if things don't go well, or start self-injections (8 days). He didn't seem too optimistic.

Has anyone else has a decreased response with increased clomid dosage? Did 150mg make a difference for anyone and produce healthy and viable follciles?

Any help is appreciated.
Thank you!

lizadeller · 07-09-2009, 08:39 AM

Clomiphene is an orally-administered, nonsteroidal agent which may induce ovulation in anovulatory women in appropriately selected cases. The ovulatory response to cyclic clomiphene therapy appears to be mediated through increased output of pituitary gonadotropins, which in turn stimulate the maturation and endocrine activity of the ovarian follicle and the subsequent development and function of the corpus luteum. The role of the pituitary is indicated by increased urinary excretion of gonadotropins and by the response of the ovary, as manifested by increased urinary estrogen excretion. Antagonism of competitive inhibition of endogenous estrogen may play a role in the action of clomiphene on the pituitary.