Quote:
Originally Posted by sheepiegirl  I just looked something up about DES and it said that 3rd generation is fine |
There's no clear cut answer on DES granddaughters:
DES granddaughters may be at risk http://www.obgyn.net/displayarticle....icles/des_1013
=====
DES Grandchildren http://www.desaction.org.au/overview.htm
This represents an overview of DES-related health outcomes for DES grandchildren. It is based on our interpretation of the medical research available (very little, in relation to DES grandchildren), and our mutually shared observations.
We are not saying that there is a direct causal link between DES exposure and these health outcomes, rather that there appears to be a pattern of association.
There is great individual variation when it comes to the long-term effects of an endocrine disruptor. Hopefully most DES grandchildren will sail through life experiencing few, if any, of these health outcomes. Others may be some effects, but not in others. It all depends of the timing on the exposure and the individual's own chemical defence system - whether it is vulnerable to the potential disruption.
Animal research, using sophisticated modelling techniques, show that DES "granddaughter" and "grandson" mice developed reproductive tract cancer, but did not have impaired fertility.
A small preliminary study in the Netherlands on sons of DES daughters showed that the DES grandsons had significantly higher rate of hypospadias compared to a control group.
Those of us that are parents are very concerned about the possibility of 3rd generation effects, in terms of cancer but also other conditions.
Our children are in the teenage to mid 20s range and we have noted patterns of poly cystic ovary syndrome; menstrual problems; asthma; clinical depression in early teens; severe mood swings; specific learning difficulties, attention deficit conditions; panic attacks and anxiety conditions; skin and other allergies; and weight problems.
====
Source:
http://www.cdc.gov/des/consumers/abo...offspring.html
(kat note: it was a small study)
Third-generation children (the offspring of DES Daughters and Sons) are just beginning to reach the age when relevant health problems (such as reproductive tract problems), can be studied.
A study of the health risks for the granddaughters of women prescribed DES while pregnant, or third-generation daughters, was published in 2002. The researchers compared findings of pelvic examinations of 28 DES Granddaughters with findings noted in their mothers (DES Daughters). Even though abnormalities were present in more than 60% of DES Daughters, no abnormalities were found in the DES Granddaughters (Kaufman, 2002).
DES Grandsons are being studied at the Netherlands Cancer Institute. Early research reported that hypospadias, misplaced opening of the penis, occurred 20 times more frequently among sons of DES Daughters (Klip, 2002).
------
DES Grandchildren (Offspring of DES Daughters and DES Sons)
http://www.desaction.org/desgrandchild.htm
Delayed Menstruation Regularity – DES Granddaughters participating in the long-running National Cancer Institute DES Follow-up Study reported menstruation starting at about the same age as unexposed women. But it took longer for DES Granddaughters to achieve regular menstrual periods, meaning a period is predictable within five days. This small study also hints at the possibility that infertility may be more frequent in DES Granddaughters, but the researchers are quick to point out that further studies are needed.
Hypospadias – A study done by the Netherlands Cancer Institute indicates that male children of DES Daughters may be at greater risk for this birth defect than unexposed individuals. Hypospadias is a condition where the urethral opening on the penis is in the wrong place, emerging somewhere down the penis shaft instead of at the tip. In many cases hypospadias can be corrected with surgery. Of note is that other studies have failed to replicate this finding.
Tumor Growth – Animal studies indicate a higher rate of tumor growth in DES Grandson and Granddaughter mice than in unexposed animals. But researchers caution that more studies are needed to prove conclusively that this finding in DES-exposed mice also occurs in humans.
Des 
