Saturday 28 May 2005
Donor ovarian response unperturbed by multiple cycles
Source: American Journal of Obstetrics and Gynecology 2005; 192: 1382-4
Investigating whether the ovarian response of oocyte donors declines with repeated stimulation cycles.
The ovarian response of an oocyte donor to exogenous gonadotropins does not appear to diminish after multiple controlled ovarian hyperstimulation (COH) cycles, study findings indicate.
It has been suggested that consecutive COH cycles may have a blunting effect on the ovarian response such that the gonadotropin dose needed to achieve follicular maturation increases, explain Akas Jain and colleagues from University of Cincinnati Medical Center in Ohio, USA.
To investigate whether repeating COH cycles in oocyte donors influences clinical outcome, the team reviewed the charts of 62 oocyte donors who underwent multiple cycles at their institution between 1992 and 2003, including those for 45 young healthy women who underwent two cycles and 17 women who underwent three.
The results showed that cycle parameters—including peak estradiol concentration, days of gonadotropin stimulation, total number of gonadotropin ampules used, numbers of follicles greater than 15 mm in diameter, number of oocytes retrieved, and clinical pregnancy rate—did not differ significantly among cycles for donors who underwent a second or third cycle.
"Therefore, we conclude that oocyte donors can be invited for up to three cycles without a negative effect on ovarian response to gonadotropins, number of mature oocytes retrieved, embryo quality, or pregnancy rates," writes the team.
Posted: 26 May 2005
http://www.obgynworld.com/international/news/2005/Week_21/Day_4/Donor_ovarian_respon.asp 
Donor ovarian response unperturbed by multiple cycles(article) 
