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Old 06-15-2006, 04:25 PM   #1 (permalink)
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Arrow Drug interactions w/thyroid hormone

I found this interesting chart on Harvard Health and thought I'd share. Hugs, Lisa

Examples of Drug Interactions with Thyroid Hormone

Drugs that Inhibit Thyroid Hormone
Drugs that are Enhanced by Thyroid Hormone
Drugs that are Suppressed by Thyroid Hormone
Drugs that Reduce Natural Thyroid Hormone Levels and May Cause Hypothyroidism

Iron supplements (even low doses found in multivitamins).
Calcium carbonate supplements.
Aluminum-containing antacids (e.g., Maalox).
Drugs used to reduce cholesterol levels by binding bile acids. Include colestipol (Colestid) and cholestyramine (Questran). Take four to five hours apart.
Estrogens in oral contraceptives and hormone replacement therapy. May need to increase thyroid hormone while taking estrogen. Need to monitor thyroid after withdrawal from estrogen.
Raloxifene (Evista), a designer-estrogen used for osteoporosis. (Evidence suggests interaction is weak.)
Sucralfate (Carafate). Take at least two hours apart.
Epinephrine (adrenaline) injections. Thyroid hormone may increase the risk of serious side effects in heart disease patients given this agent.
Warfarin, a blood thinner. Doses of this medication may need to be reduced if thyroid treatment is started after blood thinning treatments have begun.
Many antidepressants. In some cases, potency of both antidepressants and thyroid hormones may increase.
Diabetic Drugs. Diabetic patients taking thyroid hormone may need additional insulin or oral hypoglycemic drugs. Stopping or reducing thyroid hormone may increase the risk of hypoglycemia.
Digoxin. Patients with heart disease may need to increase their dosage of digoxin (Lanoxin).
Lithium. This drug, used in bipolar disorders, has multiple effects on thyroid hormone synthesis and secretion.
Amiodarone (Cordarone). This drug, used to treat abnormal heart rhythms, contains iodine and can induce hyper- or hypothyroidism, particularly in patients with an existing thyroid problem.
Antiseizure drugs used for epilepsy, including phenytoin and carbamazepine.
Interferons and interleukins used in hepatitis, multiple sclerosis, and other conditions. Drugs increase thyroid auto-antibodies.
Rifampin, used for tuberculosis.
Some drugs used for cancer chemotherapy.
Interferon.
Large doses of selenium, a common over-the-counter supplement
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Old 06-16-2006, 01:39 AM   #2 (permalink)
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Fantastic info, thanks! I reformatted it so it's easier to read, and the link is below for anyone who wants to see the actual chart. Lots of other good info at that site, too.

Drugs that Inhibit Thyroid Hormone

Iron supplements (even the doses found in multivitamins).

Calcium carbonate supplements

Aluminum-containing antacids (such as Maalox). (

Drugs used to decrease cholesterol levels by binding bile acids, such as colestipol (Colestid) and cholestyramine (Questran) (take four to five hours apart).

Estrogens, including those found in oral contraceptives and hormone replacement therapy. May need to increase thyroid hormone while taking estrogen. Need to monitor thyroid after withdrawal from estrogen.

Sucralfate (Carafate) (take at least two hours apart).

Drugs that Are Enhanced by Thyroid Hormone

Epinephrine (adrenaline) injections. Thyroid hormone may increase the risk of serious side effects in heart disease patients given this agent.

Warfarin (Coumadin), a blood thinner. Doses of this medication may need to be reduced if thyroid treatment is started after blood thinning treatments have begun.

Many antidepressants. In some cases, potency of both antidepressants and thyroid hormones may increase.

Drugs that Are Suppressed by Thyroid Hormone

Insulin or Insulin-Sensitizers. Diabetic patients taking thyroid hormone may need additional insulin or oral hypoglycemic drugs. Stopping or reducing thyroid hormone may increase the risk of hypoglycemia.

Digoxin. Patients with heart disease may need to increase their dosage of digoxin (Lanoxin).

Drugs that Reduce Natural Thyroid Hormone Levels and May Cause Hypothyroidism

Lithium. This drug is used in bipolar disorders and has multiple effects on thyroid hormone synthesis and secretion.

Amiodarone (Cordarone). This drug, used to treat abnormal heart rhythms, contains iodine and can induce hyper- or hypothyroidism, particularly in patients with an existing thyroid problem.

Antiseizure drugs used for epilepsy, including phenytoin and carbamazepine.

Rifampin, used for tuberculosis.

Some drugs used for cancer chemotherapy.

Large doses of selenium, a common over-the-counter supplement.

http://72.14.209.104/search?q=cache:...s&ct=clnk&cd=3

Linda
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Met 2000mg since 2001, started Glucophage XR 4/22/04, then switched to Met ER 6/04; also: multi, Vit. C, Vit. E, B12/folic acid combo, fish oil & borage oil combo, garlic capsules, cinnamon, Vitex, calcium with magnesium/zinc, biotin, CoQ10, selenium,iron
Other meds: Verapamil and Altace(for blood pressure)
Started laser hair removal 7/29/03, completed 3/04 (it works!)
UAE for fibroid 3/24/03 and 3/16/04
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Old 06-19-2006, 07:49 PM   #3 (permalink)
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Thanks Linda, that was great of you to format it. I didn't realize it lost the graph when I posted it. I happen to find it because after being on sythorid for 6 weeks I seemed to be having more pcos symptoms and believe I need to have my 1500mg of met increased after viewing chart. Hope it helps others as well. Hugs, Lisa
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Old 06-19-2006, 10:51 PM   #4 (permalink)
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Lisa,

Please keep in mind that Met may artificially lower your TSH level (you posted that study, in fact), thus making your doctor think that you are on enough thyroid meds when in fact you may need more of them (or a T3 med thrown in). When docs go by TSH alone, the patient is often left with being under-replaced and often feeling worse than before starting treatment (because the thyroid gland reduces its output of thyroid hormone due to the thyroid meds you are taking). You should try to get your doc to run free T4 and free T3 tests to really see how much thyroid hormone your body is using.

For those interested in reading the study that Lisa posted a few months ago about TSH being lowered by Met, here is the link:

TSH suppression with Metformin

Linda
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dx pcos 1984, type II diabetes 2001, also hypertension
Met 2000mg since 2001, started Glucophage XR 4/22/04, then switched to Met ER 6/04; also: multi, Vit. C, Vit. E, B12/folic acid combo, fish oil & borage oil combo, garlic capsules, cinnamon, Vitex, calcium with magnesium/zinc, biotin, CoQ10, selenium,iron
Other meds: Verapamil and Altace(for blood pressure)
Started laser hair removal 7/29/03, completed 3/04 (it works!)
UAE for fibroid 3/24/03 and 3/16/04
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