FAQ About Metformin - Page 4

Miss-Meme · 06-23-2004, 10:31 PM

ChristyZ,

I have seen a lot of questions like this lately:

'Met and HSG test
I read on one site that you should be off of Met for a few days before the HSG test, but my doc said I could stay on it. Has anyone stayed or gone off it for the test?'

I thought that maybe you might want to put the answer in the FAQ's.

My pharmacist called the makers and they told him that if it is a IV dye then you need to stop the night before and wait two days after to start again. But HSG is not an IV dye, so there is no need to stop it.

christyz · 06-28-2004, 06:27 PM

There is no "black and white" answer for this one...the medical information is conflicting and although the manufacturer's suggest discontinuing it for any procedure involving dyes, it is a decision that varies greatly from Doctor to Doctor.

The info I have directly conflicts with yours: "X-ray dye Metformin should be stopped at the time of, or just prior to a procedure using X- ray dye containing iodine. The kidneys clear X-ray dye and rare cases of diminished kidney function have occurred because of the dye. Since the kidney clears metformin, it could cause a build-up of metformin and potentially increase the risk of lactic acidosis. The procedures that use iodinated dye include the hysterosalpingogram (HSG) in evaluation of infertility, intravenous pyleogram (VIP) often to exclude a kidney stone or evaluate the urinary tract for recurrent infection and abnormalities, evaluation for gall bladder disease (cholangiogram), and tests to evaluate for blood clots, coronary artery function (angiogram), and CT / MRI scans. Metformin can be safely started in 48 hours if there have been no problems with the procedures.

Surgery The same rationale for withholding metformin before procedures using X-ray dye can be said for surgery. Metformin should be discontinued until a regular diet and fluid intake has resumed."

So women need to speak directly with their physician to determine what course of action to take before a procedure. Some Dr's are more careful than others, and are more particular about this issue than others.

Thanks for posting, Meme! Good Luck with that HSG..I had one 4.5 years ago and a month later I was pregnant!

claire_f · 07-03-2004, 02:03 PM

First, great thread - so informative! I've browsed through it many times

.

A while ago, someone was posting about whether met is considered a class B or class C drug. In the FAQ's here it's listed as class C. I just looked it up on inciid.org, and under the PCOS FAQ's, it lists met as class B (which I have heard before, but wanted to look it up for myself).

"There are some studies that indicate continuing the medication may reduce the risk of miscarriage. The long-term risks to the baby are not known, but many apparently healthy babies have been born to women who used metformin while pregnant. Metformin is a Pregnancy Category B drug, meaning that it has not been known to cause birth defects in rats, but there are no adequate studies in pregnant women and the choice to continue metformin should be based on whether one considers the potential benefits to outweigh the risks. This is an area where a woman and her doctor have to weigh the risks and benefits together."

http://www.inciid.org/faq/pcos7.html

Just thought I'd add that in...

Thanks

Claire

MsSuziQ · 07-16-2004, 11:48 AM

[quote]Originally posted by christyz
[b]Welcome to the Metformin Forum!
Met is a CLASS C drug (http://www.inciid.org/transcripts/coulam071399.html), which means it is commonly known as safe to a fetus, but has had few long term studies, so some are understandably hesitant to continue it during pregnancy. The most recent human studies are showing taking Met during pregnancy decreases the high miscarriage rate of PCOS women (http://www.fertilityplus.org/faq/metformin.html#pg) It is also showing a decrease in the incidence of gestational diabetes in PCOS ladies: (http://www.medscape.com/viewarticle/432639_3).

After doing research on my own, I've found this information to be questionable. In my research, I've found Metformin to be a Pregnancy Class B drug. http://my.webmd.com/hw/drug_data/d03...p?bn=Metformin.

christyz · 07-20-2004, 03:31 PM

Thanks everybody...The thread has been updated, particularly the metformin studies section. One of the studies that was listed has been completed (will post the results when they are published), but according to the website, Duke University's study is ongoing and is continuing to accept applicants. Any ladies who wish to achieve pregnancy and meet the other criteria, plus who can access one of their clinics in CA, CO, TX, AL, VA, NJ, PA, or MI, will want to get more info.

http://www.clinicaltrials.gov/ct/sho...61?amp;order=1

http://rmn.dcri.duke.edu/index.html

brdway · 08-06-2004, 09:25 PM

hello I'm new to the board but I wanted to comment on your articel I just started taking met last month when you first take it you will be sick your head hurts and you go to the restroom alot but after two weeks it gets better just keep taking it I was having the same symtoms but guess what at first I never had a normal cycle but after taking it for four weeks guess what I SAW MY CYCLE SO I KNOW IT'S WORKING SO KNOW MY NEXT STEP is to try and figure out when I ovulate hang in there!!!!!!!!!!!!!!!!

sabreena · 08-13-2004, 12:36 PM

Hi Girls,
I am really worried abou the excess hairs i have all over, my hairiness started when i started my period i was 10.
and now i am 27 and i have very low self esteem becasue of this and i dont let men see me naked, recently it has started to get really bad i feel like i am turning into a wolf.
I have got hairs all over my tummy that i quite think, it used to be just my lower abdomen before.
I had hairs around my niples before but now it is all over my breasts which makes me feel really down and depressed.
i have got hairs on my chest, my chin i shave every day even though i have been having laser hair removal treatments it hasnt helped a lot...
i am scared of the future, really scared...
I dont want to end up alone and miserable, my last relation ship ended bacause of my weight problem.
I am now 15 stones in weight, and i am only 5ft tall, i have got underactive thyroid and i am on 200mg thyroxien a day...
i also suffer from aneamia, and PCOS...
is there anyone out there in the same boat as me, if so please get in touch..
I get really depressed sometimes and constantly feel self concious and i have zero confidence...
Please help....
I have heard of metformin and dianette, does it help?? can i take the two together??? can i take them with thyroxien???
Please help!!!
Regards
Sabreena x

raej10 · 08-13-2004, 05:23 PM

Should I continue monitoring blood glucose levels while on met? I was having 'hypoglycemic episodes' and all of my blood tests came back normal (as they usually do) but I am concerned that the met my make my blood sugar too low...

any advice appreciated!!!

yayagirl · 08-14-2004, 04:29 AM

Hi ~ I want to check out the links to the articles under the Met and Breastfeeding heading, but they' don't seem to work. Anyone have updated links?

Thanks

christyz · 08-25-2004, 02:21 PM

Sorry for the delay.

I've added these to the original thread, but here are the updated links:

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=12436333

http://www.mja.com.au/public/issues/...0804_fm-6.html

And if anybody else finds any broken link, let me know.

Hope it helps!

xrayandee · 08-27-2004, 12:05 AM

As a radiographer, I just wanted to add information about metformin & xray dyes. The most recent standard that my hospital holds to is that metformin need only be stopped for exams requiring intravenouse injection of iodine dye. That means exams that require the iodine dye to be injected directly into the blood stream. This includes some CT (aka CAT or Computed Tomography) exams, IVP for urinary tract studies,and angiogram studies of the heart, veins, arteries etc. However, there are some exams that use iodine dye, but not in the blood stream & therefore are not an issue according to my hospitals stance. The HSG falls into this catagory because the dye is allowed to flow into the uterus backwards through the cervix (like a reverse period). The majority of the dye then comes back out through the vagina. Also in cholangiograms the dye is injected directly into the bile duct system which is part of the intestinal system. Most of it passes through the intestines & released that way. MRI exams do not use iodine as they involve magnets rather than xrays.
My hospitals policy is patients may take their metformin prior to the exam & then must stop taking it until they get a new creatnine test done. This test checks kidney function and must be done 24-48 hours from the time the iodine dye is injected into the system.
Many physicians are unclear about hospital policy, so I would reccommended anyone with questions about a specific hospital or test contact that radiology department directly as they are the ones who set up the guidelines to be followed.
Also, while I am medically trained, I am not a doctor. My opinions are my own and are intended only to be informational.

asenith · 10-01-2004, 09:28 PM

That was great information Christy. My doctor just gave me a prescription for it and reading about the nausea and diarreah sounds a little scary, but I will get though it cause I have to have some hope that something will help me to become pregnant.

christyz · 10-05-2004, 02:49 PM

Welcome Asen..a fellow Canadian! My DH's family is in AB.

Most people find the side effects are better if they dose up slowly. Can you talk to your physician about dosing up this way? By increasing really gradually, your body gets accustomed to it with fewer probelms generally.

Good luck to you!

Determined07 · 10-10-2004, 11:56 PM

Wow, the information provided by Christy was awesome. I have hope now. I definitely will stick with the meds and monitor my progress. I would love to be another success story like Christy. After 10 years of juggling physicians, I have finally found one that prescribed Glucophage/Meformin for me. I have been taking it since late July. Now that I know it has worked for others. I will make sure I take it when I should. At first I was skeptical.

I definitely have the symptons of PCOS:

Irregular/None menstrual cycles
Thinning of hair in crown
Adult acne
Weight gain (13 pounds since May)

I am so glad to know I have other women to chat with. It gets lonely thinking.... Does anyone understand my pain?

oreosmama · 10-26-2004, 03:52 PM

Determined07 : glad to meet you. I noticed you said you started metformin/glucophage in July. What mg are you currently taking?

since you don't have regular cycles were you on bcpills prior to the metformin? or what kept you regular?

I am in a very similar situation as you. I never had regular cycles unless I was on Clomid or bc pills. I have been on metformin 1500mg for almost 6months and I had my very first period the other day. I almost cried. Ok, maybe I did cry..h ehe
My breasts were soooo sore the week before, and my back was killing me. Then viola' I started out of the blue! Yay God!

I'd love to hear back from you.

Oreosmama

06-23-2004, 10:31 PM	#46 (permalink)
Miss-Meme Member since Aug. 2003 Join Date: Mar 2004 Location: Southern IN Posts: 5,205 My Mood: Points: 23,197.88 Bank: 90,496,661.32 Total Points: 90,519,859.20 Donate	ChristyZ, I have seen a lot of questions like this lately: 'Met and HSG test I read on one site that you should be off of Met for a few days before the HSG test, but my doc said I could stay on it. Has anyone stayed or gone off it for the test?' I thought that maybe you might want to put the answer in the FAQ's. My pharmacist called the makers and they told him that if it is a IV dye then you need to stop the night before and wait two days after to start again. But HSG is not an IV dye, so there is no need to stop it. __________________ Amy (31) SAHM & To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. Husband (35) Son (1 year) Be your own boss! Join now for $29 during the month of April! PM to find out how!! Married May 1995 DX Feb 1996 To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.

06-28-2004, 06:27 PM	#47 (permalink)
christyz Running & Biking Fool! Join Date: Aug 2002 Location: SK, CANADA Posts: 9,523 Points: 19,570.01 Bank: 3,348,243.84 Total Points: 3,367,813.85 Donate	There is no "black and white" answer for this one...the medical information is conflicting and although the manufacturer's suggest discontinuing it for any procedure involving dyes, it is a decision that varies greatly from Doctor to Doctor. The info I have directly conflicts with yours: "X-ray dye Metformin should be stopped at the time of, or just prior to a procedure using X- ray dye containing iodine. The kidneys clear X-ray dye and rare cases of diminished kidney function have occurred because of the dye. Since the kidney clears metformin, it could cause a build-up of metformin and potentially increase the risk of lactic acidosis. The procedures that use iodinated dye include the hysterosalpingogram (HSG) in evaluation of infertility, intravenous pyleogram (VIP) often to exclude a kidney stone or evaluate the urinary tract for recurrent infection and abnormalities, evaluation for gall bladder disease (cholangiogram), and tests to evaluate for blood clots, coronary artery function (angiogram), and CT / MRI scans. Metformin can be safely started in 48 hours if there have been no problems with the procedures. Surgery The same rationale for withholding metformin before procedures using X-ray dye can be said for surgery. Metformin should be discontinued until a regular diet and fluid intake has resumed." So women need to speak directly with their physician to determine what course of action to take before a procedure. Some Dr's are more careful than others, and are more particular about this issue than others. Thanks for posting, Meme! Good Luck with that HSG..I had one 4.5 years ago and a month later I was pregnant! __________________ Christy 33 yrs, 1 precious hubby, 2 miracle kids, At Goal Wt for 4 yrs, Trygly's down 445 pts, Free Androgen down from 20 to 2, 3 half 'thons ran, 2 mtns hiked, 1 crazy run in the Rockies, 4 forest trail races, profiled in 2 magazines...1 woman determined to kick PCOS butt! To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. Before & Aug 2007 '08: Duathlon and another half?

07-03-2004, 02:03 PM	#48 (permalink)
claire_f Triathlon Mama... x2! Join Date: Jan 2003 Location: Washington Posts: 3,587 My Mood: Points: 12,884.83 Bank: 0.00 Total Points: 12,884.83 Donate	First, great thread - so informative! I've browsed through it many times . A while ago, someone was posting about whether met is considered a class B or class C drug. In the FAQ's here it's listed as class C. I just looked it up on inciid.org, and under the PCOS FAQ's, it lists met as class B (which I have heard before, but wanted to look it up for myself). "There are some studies that indicate continuing the medication may reduce the risk of miscarriage. The long-term risks to the baby are not known, but many apparently healthy babies have been born to women who used metformin while pregnant. Metformin is a Pregnancy Category B drug, meaning that it has not been known to cause birth defects in rats, but there are no adequate studies in pregnant women and the choice to continue metformin should be based on whether one considers the potential benefits to outweigh the risks. This is an area where a woman and her doctor have to weigh the risks and benefits together." http://www.inciid.org/faq/pcos7.html Just thought I'd add that in... Thanks Claire __________________ Claire - 30!, DH 31 Mommy to my sweet boys: David Alexander 12/8/04 & Grayson Christopher 5/19/07 To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.

07-16-2004, 11:48 AM	#49 (permalink)
MsSuziQ Mommy of 2! Join Date: Jul 2004 Location: Gallatin, Tennessee Posts: 7,150 My Mood: MyEbay : Points: 591.38 Bank: 17,255,340.00 Total Points: 17,255,931.39 Donate	Re: FAQ About Metformin [quote]Originally posted by christyz [b]Welcome to the Metformin Forum! Met is a CLASS C drug (http://www.inciid.org/transcripts/coulam071399.html), which means it is commonly known as safe to a fetus, but has had few long term studies, so some are understandably hesitant to continue it during pregnancy. The most recent human studies are showing taking Met during pregnancy decreases the high miscarriage rate of PCOS women (http://www.fertilityplus.org/faq/metformin.html#pg) It is also showing a decrease in the incidence of gestational diabetes in PCOS ladies: (http://www.medscape.com/viewarticle/432639_3). After doing research on my own, I've found this information to be questionable. In my research, I've found Metformin to be a Pregnancy Class B drug. http://my.webmd.com/hw/drug_data/d03...p?bn=Metformin. __________________ To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.

07-20-2004, 03:31 PM	#50 (permalink)
christyz Running & Biking Fool! Join Date: Aug 2002 Location: SK, CANADA Posts: 9,523 Points: 19,570.01 Bank: 3,348,243.84 Total Points: 3,367,813.85 Donate	Thanks everybody...The thread has been updated, particularly the metformin studies section. One of the studies that was listed has been completed (will post the results when they are published), but according to the website, Duke University's study is ongoing and is continuing to accept applicants. Any ladies who wish to achieve pregnancy and meet the other criteria, plus who can access one of their clinics in CA, CO, TX, AL, VA, NJ, PA, or MI, will want to get more info. http://www.clinicaltrials.gov/ct/sho...61?amp;order=1 http://rmn.dcri.duke.edu/index.html __________________ Christy 33 yrs, 1 precious hubby, 2 miracle kids, At Goal Wt for 4 yrs, Trygly's down 445 pts, Free Androgen down from 20 to 2, 3 half 'thons ran, 2 mtns hiked, 1 crazy run in the Rockies, 4 forest trail races, profiled in 2 magazines...1 woman determined to kick PCOS butt! To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. Before & Aug 2007 '08: Duathlon and another half?

08-06-2004, 09:25 PM	#51 (permalink)
brdway Registered User Join Date: Jul 2004 Location: tennesse Posts: 2 Points: 45.00 Bank: 0.00 Total Points: 45.00 Donate	met hello I'm new to the board but I wanted to comment on your articel I just started taking met last month when you first take it you will be sick your head hurts and you go to the restroom alot but after two weeks it gets better just keep taking it I was having the same symtoms but guess what at first I never had a normal cycle but after taking it for four weeks guess what I SAW MY CYCLE SO I KNOW IT'S WORKING SO KNOW MY NEXT STEP is to try and figure out when I ovulate hang in there!!!!!!!!!!!!!!!!

08-13-2004, 12:36 PM	#52 (permalink)
sabreena Registered User Join Date: Aug 2003 Location: Manchester UK Posts: 54 Points: 2,565.50 Bank: 0.00 Total Points: 2,565.50 Donate	What should i do??? Hi Girls, I am really worried abou the excess hairs i have all over, my hairiness started when i started my period i was 10. and now i am 27 and i have very low self esteem becasue of this and i dont let men see me naked, recently it has started to get really bad i feel like i am turning into a wolf. I have got hairs all over my tummy that i quite think, it used to be just my lower abdomen before. I had hairs around my niples before but now it is all over my breasts which makes me feel really down and depressed. i have got hairs on my chest, my chin i shave every day even though i have been having laser hair removal treatments it hasnt helped a lot... i am scared of the future, really scared... I dont want to end up alone and miserable, my last relation ship ended bacause of my weight problem. I am now 15 stones in weight, and i am only 5ft tall, i have got underactive thyroid and i am on 200mg thyroxien a day... i also suffer from aneamia, and PCOS... is there anyone out there in the same boat as me, if so please get in touch.. I get really depressed sometimes and constantly feel self concious and i have zero confidence... Please help.... I have heard of metformin and dianette, does it help?? can i take the two together??? can i take them with thyroxien??? Please help!!! Regards Sabreena x

08-13-2004, 05:23 PM	#53 (permalink)
raej10 Registered User Join Date: Aug 2004 Location: Saskatchewan, Canada Posts: 11 Points: 254.00 Bank: 0.00 Total Points: 254.00 Donate	met and blood glucose levels Should I continue monitoring blood glucose levels while on met? I was having 'hypoglycemic episodes' and all of my blood tests came back normal (as they usually do) but I am concerned that the met my make my blood sugar too low... any advice appreciated!!!

08-14-2004, 04:29 AM	#54 (permalink)
yayagirl Registered User Join Date: Feb 2003 Location: The Holy Land Posts: 47 Points: 975.41 Bank: 0.00 Total Points: 975.41 Donate	Hi ~ I want to check out the links to the articles under the Met and Breastfeeding heading, but they' don't seem to work. Anyone have updated links? Thanks

08-25-2004, 02:21 PM	#55 (permalink)
christyz Running & Biking Fool! Join Date: Aug 2002 Location: SK, CANADA Posts: 9,523 Points: 19,570.01 Bank: 3,348,243.84 Total Points: 3,367,813.85 Donate	Sorry for the delay. I've added these to the original thread, but here are the updated links: http://www.ncbi.nlm.nih.gov/entrez/q..._uids=12436333 http://www.mja.com.au/public/issues/...0804_fm-6.html And if anybody else finds any broken link, let me know. Hope it helps! __________________ Christy 33 yrs, 1 precious hubby, 2 miracle kids, At Goal Wt for 4 yrs, Trygly's down 445 pts, Free Androgen down from 20 to 2, 3 half 'thons ran, 2 mtns hiked, 1 crazy run in the Rockies, 4 forest trail races, profiled in 2 magazines...1 woman determined to kick PCOS butt! To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. Before & Aug 2007 '08: Duathlon and another half?

08-27-2004, 12:05 AM	#56 (permalink)
xrayandee Registered User Join Date: Aug 2004 Location: kenosha, WI USA Posts: 2 Points: 52.00 Bank: 0.00 Total Points: 52.00 Donate	As a radiographer, I just wanted to add information about metformin & xray dyes. The most recent standard that my hospital holds to is that metformin need only be stopped for exams requiring intravenouse injection of iodine dye. That means exams that require the iodine dye to be injected directly into the blood stream. This includes some CT (aka CAT or Computed Tomography) exams, IVP for urinary tract studies,and angiogram studies of the heart, veins, arteries etc. However, there are some exams that use iodine dye, but not in the blood stream & therefore are not an issue according to my hospitals stance. The HSG falls into this catagory because the dye is allowed to flow into the uterus backwards through the cervix (like a reverse period). The majority of the dye then comes back out through the vagina. Also in cholangiograms the dye is injected directly into the bile duct system which is part of the intestinal system. Most of it passes through the intestines & released that way. MRI exams do not use iodine as they involve magnets rather than xrays. My hospitals policy is patients may take their metformin prior to the exam & then must stop taking it until they get a new creatnine test done. This test checks kidney function and must be done 24-48 hours from the time the iodine dye is injected into the system. Many physicians are unclear about hospital policy, so I would reccommended anyone with questions about a specific hospital or test contact that radiology department directly as they are the ones who set up the guidelines to be followed. Also, while I am medically trained, I am not a doctor. My opinions are my own and are intended only to be informational. __________________ Those who say it can't be done should get out of the way of those who are doing it.

10-01-2004, 09:28 PM	#57 (permalink)
asenith casual observer Join Date: Apr 2004 Location: Red Deer, Alberta, Canada Posts: 149 Points: 944.00 Bank: 0.00 Total Points: 944.00 Donate	That was great information Christy. My doctor just gave me a prescription for it and reading about the nausea and diarreah sounds a little scary, but I will get though it cause I have to have some hope that something will help me to become pregnant. __________________ diagnose January 2004 trying to conceive for 1year before this came out of the bag

10-05-2004, 02:49 PM	#58 (permalink)
christyz Running & Biking Fool! Join Date: Aug 2002 Location: SK, CANADA Posts: 9,523 Points: 19,570.01 Bank: 3,348,243.84 Total Points: 3,367,813.85 Donate	Welcome Asen..a fellow Canadian! My DH's family is in AB. Most people find the side effects are better if they dose up slowly. Can you talk to your physician about dosing up this way? By increasing really gradually, your body gets accustomed to it with fewer probelms generally. Good luck to you! __________________ Christy 33 yrs, 1 precious hubby, 2 miracle kids, At Goal Wt for 4 yrs, Trygly's down 445 pts, Free Androgen down from 20 to 2, 3 half 'thons ran, 2 mtns hiked, 1 crazy run in the Rockies, 4 forest trail races, profiled in 2 magazines...1 woman determined to kick PCOS butt! To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. Before & Aug 2007 '08: Duathlon and another half?

10-10-2004, 11:56 PM	#59 (permalink)
Determined07 Registered User Join Date: Oct 2004 Location: Houston Posts: 3 Points: 95.00 Bank: 0.00 Total Points: 95.00 Donate	Metformin Wow, the information provided by Christy was awesome. I have hope now. I definitely will stick with the meds and monitor my progress. I would love to be another success story like Christy. After 10 years of juggling physicians, I have finally found one that prescribed Glucophage/Meformin for me. I have been taking it since late July. Now that I know it has worked for others. I will make sure I take it when I should. At first I was skeptical. I definitely have the symptons of PCOS: Irregular/None menstrual cycles Thinning of hair in crown Adult acne Weight gain (13 pounds since May) I am so glad to know I have other women to chat with. It gets lonely thinking.... Does anyone understand my pain?

10-26-2004, 03:52 PM	#60 (permalink)
oreosmama Christian Cyster Join Date: May 2004 Location: Texas Posts: 40 Points: 200.00 Bank: 0.00 Total Points: 200.00 Donate	Determined07 : glad to meet you. I noticed you said you started metformin/glucophage in July. What mg are you currently taking? since you don't have regular cycles were you on bcpills prior to the metformin? or what kept you regular? I am in a very similar situation as you. I never had regular cycles unless I was on Clomid or bc pills. I have been on metformin 1500mg for almost 6months and I had my very first period the other day. I almost cried. Ok, maybe I did cry..h ehe My breasts were soooo sore the week before, and my back was killing me. Then viola' I started out of the blue! Yay God! I'd love to hear back from you. Oreosmama __________________ Monica DX PCOS 1998 DX IR 1999 1500 mg Metformin Synthroid 160**155150G145*140**OAL