mommy1

Can having high E2 be a sign of hypothyroid?

I found out in June that my cd3 b/w shows high levels of E2 over the past few years. It may explain why recently I've stopped responding to meds to produce follicles. I won't see an endo until November 19th so won't have any tests done until then. Very frustrating!

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hnelson

I am no expert, but when researching hypothyroidism (I was recently diagnosed subclinical) I saw that estrogen may inhibit the action of T4 therefore worsening (or causing?) hypothyroidism. So maybe high E2 is causing hypothyroidism.

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mommy1

Thank you! I was starting to think I was going crazy! lol. I was finding the same thing! If you 'google' high e2 and hypothyroid together you get alot of information. I just wish I didn't have to wait until November to see a dr!! My family dr will only test TSH (he said "I'll leave everything else to the endo") which for me has been coming back normal at least at last check a year ago, and my RE will do the T3 and T4 (upon request only) but I don't know if he will treat me for hypothyroid if I infact have it. *sigh* Soooo very frustrating!! What does it mean to be subclinical? Are you being treated and if so how are you feeling now?

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hnelson

I'm interested to hear what your RE/Endo says. In my personal experience, my RE tested then referred me to an Endo for further testing and meds.

I'm new to this, and posted similar info on another thread hoping others could give me some more information. But here are a couple of points I have found (from "American Association of Clinical Endocrinologists Medical Guideline for Clinical Practice for the Evaluation and Treatment of Hyperthyroidism and Hypothyroidism" published December 2002).

• "Subclinical hypothyroidism refers to mildly increased serum TSH levels in the setting of normal free T4 and T3 estimates" ... while "patients with clinical or overt hypothyroidism exhibit reduced free T4 estimates and increased TSH levels"
  • I have subclinical: TSH at 6.0, T4 and T3 normal, with no apparent symptoms
• "Treatment of subclinical hypothyroidism remains controversial"...."We believe that treatment is indicated in patients with TSH levels >10 mcIU/ml or in patients with TSH levels between 5 and 10 mcIU/ml in conjunction with goiter or positive anti-thyroid peroxidase antibodies (or both)"

Anyway, I've been on meds for a little over a week (25 mcg synthroid) and get checked in another 1.5 weeks for my response. I didn't have any overt symptoms before (I have recently been more tired than normal, but I think its because I've been on clomid), but I am trying to assess my energy level now and I may have more energy since starting the meds. Either way, I didn't have glaring symptoms prior, but maybe I'll feel better in general on the meds like others do. Also in 1.5 weeks I get evaluated further - more bloodwork to test for antibodies, ultrasound of my thyroid, etc. I'll learn more then.

Good luck to you!

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mommy1

Thank you. Good luck to you too!

I will be sure to update when I have some results to share.

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