Basically the glucose goes to your muscles for fuel. Insulin binds to glucose as this happens. your insulin is not either 1.) Manufactured correctly or 2.) does not bind to glucose = not all glucose goes to the muscles and is stored as fat. Thats a basice explanation. I suggest this site... www.jewishhospitalcincinnati.com
go to the right to the links to cholesterol center. Then go to the PCOS link. VERY GOOD INFORMATION!
Also check out the IR sticky thread up at the top.
__________________ Jenny
Wife to Carl and Mommy to CJ and Emily.
DX. 1999
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33 yrs, 1 precious hubby, 2 miracle kids, At Goal Wt for 4 yrs, Trygly's down 445 pts, Free Androgen down from 20 to 2, 3 half 'thons ran, 2 mtns hiked, 1 crazy run in the Rockies, 4 forest trail races, profiled in 2 magazines...1 woman determined to kick PCOS butt!
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Sorry if I missed this in the FAQ... If af normally comes as a result of progesterone dropping off if the egg is not fertilized after ovulation, then what is it about met that makes af come, even for those who are not ovulating?
Sorry if I missed this in the FAQ... If af normally comes as a result of progesterone dropping off if the egg is not fertilized after ovulation, then what is it about met that makes af come, even for those who are not ovulating?
Met helps to sensitize our cells to insulin. When we are insulin resistant, we have too much insulin circulating in our bodies. Insulin is a "master hormone", meaning it helps to regulate many other hormones in our body, including the reproductive hormones. IR leads to an imbalance in these hormones, and Met helps to normalize them again. Here's an explanation of how insulin can get things out of whack (when you see the term "Syndrome O", it means PCOS):
Quote:
Ovarian Confusion. The ovaries are supposed to produce uniquely female hormones — estrogen and progesterone — in a pattern as predictable as the phases of the moon. When bombarded with inappropriate levels of insulin hormones, the ovaries become confused, producing some estrogen but very little progesterone. To make matters worse, there is a strong tendency for confused ovaries to produce slightly higher amounts of male hormones, called androgens. Androgens like testosterone cause all sorts of problems throughout women’s bodies, but particularly in the skin, leading to unsightly hair growth, acne, darkened areas, and abnormal growths.
Ovulation Disruption. Deep within the ovaries lie the “pearls” of mankind — tiny little eggs that lie dormant for years, waiting for the right time to emerge. The eggs live in small cystic incubators called follicles, which grow each month in response to proper hormone signals. As Syndrome O gets started, insulin signals are exaggerated and inappropriate. The insulin family of hormones and androgens then conspire to block normal follicle growth and the monthly release of an egg — a process that defines ovulation. In many cases, the ovaries can become enlarged and polycystic. Ovulation disruption (also known as anovulation) is a major women’s health, lifestyle, and economic problem, leading to infertility, missed menses for months at a time, and the potential for heavy, unpredictable vaginal bleeding.
__________________ dx pcos 1984, type II diabetes 2001, also hypertension
Met 2000mg since 2001, started Glucophage XR 4/22/04, then switched to Met ER 6/04; also: multi, Vit. C, Vit. E, B12/folic acid combo, fish oil & borage oil combo, garlic capsules, cinnamon, Vitex, calcium with magnesium/zinc, biotin, CoQ10, selenium,iron
Other meds: Verapamil and Altace(for blood pressure)
Started laser hair removal 7/29/03, completed 3/04 (it works!)
UAE for fibroid 3/24/03 and 3/16/04
Criteria for entry into studies where met shown effective did not include elevated insulin levels, but rather hyperandrogenemia and anovulation: http://www.ivf.com/faqs/pcos3.html
Metformin appears to do the same for non-obese PCOS women, according to a study from the University of Medical Sciences in Poznan, Poland. Thirty nine PCOS women were given metformin for 12 weeks. They had improvements in insulin, testosterone, hirsutism and acne. (Kolodziejezyk, B et al): http://www.fertilityplus.org/faq/metformin.html
33 yrs, 1 precious hubby, 2 miracle kids, At Goal Wt for 4 yrs, Trygly's down 445 pts, Free Androgen down from 20 to 2, 3 half 'thons ran, 2 mtns hiked, 1 crazy run in the Rockies, 4 forest trail races, profiled in 2 magazines...1 woman determined to kick PCOS butt!
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How does Met work in the body? 
Another related question... 
