If you're just starting a new thyroid supplement regime, you're not going to feel instant results. Thyroid hormones take a while for the body to "accept" (so to speak), process, and metabolize. It sounds like you've got some catching up to do- a single dose is not going to suddenly satisfy your body's need for a hormone that's been in short supply for a while. As far as the fatigue is concerned, your body is adjusting to a new medication, so it should go away in a reasonable amount of time- at least it did with me and a couple of my lady friends.
That being said, when you've been on your regime for a while and go a day or two without your pills, you WILL feel results fairly quickly upon taking a dose.
__________________ "Women are meant to be loved, not understood" - Oscar Wilde
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Me (26)
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My Man (26) | Mopar
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& Sylvia
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How long..... 
