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William S Yancy Jr , Marjorie Foy , Allison M Chalecki , Mary C Vernon and Eric C Westman

Nutrition & Metabolism 2005, 2:34 doi:10.1186/1743-7075-2-34

Published 1 December 2005
Abstract (provisional)
Background

The low-carbohydrate, ketogenic diet (LCKD) may be effective for improving glycemia and reducing medications in patients with type 2 diabetes.

Methods

From an outpatient clinic, we recruited 28 overweight participants with type 2 diabetes for a 16-week, single-arm, pilot diet intervention trial. We provided LCKD counseling, with an initial goal of <20 g carbohydrate/day, while reducing diabetes medication dosages at diet initiation. Participants returned every other week for measurements, counseling, and further medication adjustment. The primary outcome was hemoglobin A1c.

Results

Twenty-one of the 28 participants who were enrolled completed the study. Twenty participants were men; 13 were White, 8 were African-American. The mean [+ SD] age was 56.0 + 7.9 years and BMI was 42.2 + 5.8 kg/m2. Hemoglobin A1c decreased by 16% from 7.5 + 1.4% to 6.3 + 1.0% (p<0.001) from baseline to week 16. Diabetes medications were discontinued in 7 participants, reduced in 10 participants, and unchanged in 4 participants. The mean body weight decreased by 6.6% from 131.4 + 18.3 kg to 122.7 + 18.9 kg (p<0.001). In linear regression analyses, weight change at 16 weeks did not predict change in hemoglobin A1c. Fasting serum triglyceride decreased 42% from 2.69 + 2.87 mmol/L to 1.57 + 1.38 mmol/L (p=0.001) while other serum lipid measurements did not change significantly.

Conclusions

The LCKD improved glycemic control in patients with type 2 diabetes such that diabetes medications were discontinued or reduced in most participants. Because the LCKD can be very effective at lowering blood glucose, patients on diabetes medication who use this diet should be under close medical supervision or capable of adjusting their medication.

http://www.nutritionandmetabolism.com/content/2/1/34

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dx pcos 1984, type II diabetes 2001, also hypertension
Met 2000mg since 2001, started Glucophage XR 4/22/04, then switched to Met ER 6/04; also: multi, Vit. C, Vit. E, B12/folic acid combo, fish oil & borage oil combo, garlic capsules, cinnamon, Vitex, calcium with magnesium/zinc, biotin, CoQ10, selenium,iron
Other meds: Verapamil and Altace(for blood pressure)
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