jaa

A peer-reviewed study published in the Journal of Clinical Endocrinology & Metabolism (Vol. 92, No. 8 3285-3291) in July 2007 that found:
The urinary 2-hydroxyestrogen level was significantly lower in subjects with PCOS, compared with normal controls (P = 0.009). Additionally, urinary 2-hydroxyestrogen levels negatively correlated with serum insulin levels in subjects with PCOS (r = –0.333, P =0 .031).

There are alternative therapies, namely i3c (indole-3-carbinol) and its derivative, dim (diindolylmethane), that change estrogen metabolism to favor 2-hydroxyestrone.

I have been taking i3c at 400mg/day for about 6 months, and I have found that it reduces my night-time cravings. It may have helped me lose weight, and reduced acne (this is more difficult to say, empirically). After ~4months of taking i3c, my triglyceride and ldl levels decreased substantially, and are now in the normal range (I've had problems with cholesterol for at least 20 years). Of course, I don't know if the i3c is responsible for this favorable lipid profile, but my habits have otherwise been unchanged.
I also tried DIM for several months, and the effects were not like i3c - I continued to wake multiple times/night hungry, and my menstrual cycles became severely uncomfortable and heavy.
Does anybody have any success (or otherwise?) stories to share about i3c or dim?