Mary's PCOS Treatment Research

MaryKate76 · 03-03-2004, 01:02 PM

(I first posted this in the Other Treatments section, but this is a better place)

I have compiled information on PCOS treatments from more than 250 clinical studies. It was too much information to post to the forum, so I made a web page for it (There are no ads, it's just a simple page). If you have any comments, please post them here. I am here to learn too, so if you see anything that is amiss in my information, I will appreciate you letting me know.

~~http://marykateroget.home.comcast.net/~~
http://members.aol.com/marykateroget/

The FAQ has brief information on all the treatments listed below and their effects on the various PCOS biochemical features.

::::Biochemical features in PCOS::::

Increased Fasting Insulin
Increased Insulin Resistance
Increased Testosterone
Increased Androstenedione
Increased LH
Increased TNF-alpha
Increased DHEAS
Increased C-reactive protein
Increased Homocysteine
Increased Prolactin
Increased blood sugar
Increased LDL Cholesterol
Increased Triglycerides
Increased MMP-2 and MMP-9
Increased Granulosa Cell VEGF

Decreased Glutathione
Decreased SHBG levels
Decreased Antioxidant status
Decreased D-Chiro-Inositol
Decreased Magnesium
Decreased FSH
Decreased Hypothalamic sensitivity
Decreased ghrelin

Obesity
Dyslipidemia
Depression
Bipolar disorder

::::Treatments:::: (or things to avoid)

Antiandrogens
Oral Birth Control Pills
Metformin XR
D-Chiro-Inositol
NAC
Calcium Citrate
Vitamin D3
Magnesium Citrate
Vitamin K
Lipoic Acid
Chromium Polynicotinate
EGCG
EPA/DHA
Biotin
D-Calcium Pantothenate
MHCP
L-Arginine
Acetyl-L-Carnitine
Taurine
Resveratrol
Curcumin
Gamma-tocopherol
Methylcobalamin
Folic Acid
B6
B-Complex
Zinc
L-Se-Methylselenocysteine
Bis-Glycinato Oxovanadium
Tocotrienols
Vitamin C
Coenzyme Q10
Glucosol
Quercetin
Manganese
Potassium
Exercise
Lower Carb Diets/Low Glycemic Index Diets
Monounsaturated fats
High fiber foods
Unrefined, whole foods
Protein intake
Gymnema Sylvestre
CLA
Bitter Melon
Trans-fats
Saturated fats
High glycemic carbs
Highly processed or refined foods

Lori74 · 03-03-2004, 08:10 PM

Wow -- you did an amazing job! Perhaps we should all print that out and take that to doctors who are clueless or misdiagnose us! I hope someone makes that a sticky....

nobimbo · 03-03-2004, 10:29 PM

Wow, excellent job, Mary!! I have saved your page and will refer others to it in the future. Thanks for all your hard work in putting this together; it will help many cysters.

Linda

Ajani · 03-04-2004, 10:28 AM

There is some good information in that site, and I'm making it a sticky.

Emmanuelle · 03-05-2004, 10:03 AM

Nice job! Just two important things you forgot to mention in terms of supplements: vitex and natural progesterone cream :-)

MaryKate76 · 03-10-2004, 05:54 AM

Thanks for your nice comments. I have expanded the FAQ, adding several more treatments to the list.

~~http://marykateroget.home.comcast.net/~~
http://members.aol.com/marykateroget/

Changes:

Removed some biochemical features since they were really symptoms
Added some biochemical features
Lowered dose of Taurine
Lowered dose of Vitamin K
Increased dose of Gamma E
Increased rating of B6, B12 and folate to two stars
Added notes to supplement Biotin with Lipoic Acid or B5
Added note that Picolinate form of Chromium may cause chromosomal damage
Added mention of Saw Palmetto extract
Added Actos and Avandia
Added Precose and Miglitol
Added Vinegar
Added Kidney Bean extract
Added depression and OCPs to benefits of Vitamin C
Added lower PAI-1 to benefits of Vitamin E, C, Metformin, Avandia and Fiber
Added depression to benefits of Magnesium and Potassium
Added PMS to benefits of Magnesium and Calcium
Added note to take amino acids on an empty stomach
Added reason why saturated fat is bad
Added mention of Trans-fats decreasing HDL
Added note about 1800mg NAC
Added TMG
Added warning about Potassium and Spironolactone
Added Calcium Pyruvate
Added Oral Progesterone and Natural Progesterone Cream
Added a link to "The Two Gram Cure"
Added GLA
Added Soy Isoflavones
Added Flax Lignans
Added Vitex
Added Licorice
Added note about piperine to Curcumin
Miscellaneous editing

MaryKate76 · 03-19-2004, 12:07 AM

More changes.... I have expanded the FAQ again, adding several notes, several more treatments, and two sample supplement regimens listing specific products and doses:

~~http://marykateroget.home.comcast.net/~~
http://members.aol.com/marykateroget/

Changes:

Added links to information sources: PubMed, PDRHealth, etc.
Added and changed some biochemical features
Added to notes about Flutamide and CYP1A2 liver enzyme
Added notes to NAC about zinc and molybdenum
Added notes on the bioavailibility of the various forms of Calcium
Added note about taking Calcium with meals
Added note that Magnesium can act as a laxative
Added note about Lipoic Acid sustained release tablets
Added note to Lipoic Acid about synergy with GLA
Added note that Chromium may lower cholesterol
Added note about Chelavite form of Chromium
Added to notes about the difference between Fish Oil and Flax Oil
Added notes about Fish Oil and gastrointestinal upset and other side effects
Increased rating of GLA
Added note to GLA about synergy with Lipoic Acid
Added 3 more references for Cinnamon
Added note about Cassia vs. true Cinnamon
Changed the dose of B5 to be variable and added note about adjusting the dose
Added note about adrenal insufficiency and B5
Added note that Calcium Pantothenate is 8.5% Calcium
Added Pantethine
Added note about taking Lipoic Acid with Acetyl-L-Carnitine
Added a reference for Taurine
Lowered rating of Arginine
Added note about Arginine and hyperglycemia
Added that curcumin has anticancer effects
Added Astaxanthin
Added Nicotinamide
Changed dosage for B-Complex
Added Garlic Extract
Added American Ginseng
Added note that Zinc can decrease copper
Lowered dose of TMG
Removed Gymnema Sylvestre from avoid section
Added note that Gymnema Sylvestre should not contribute to hyperinsulinemia
Added note that Bitter Melon can cause hypoglycemia
Added 2 example supplement regimens
Miscellaneous editing

daughty · 03-20-2004, 02:20 PM

Mary Kate, you did an awesome job! Thank you so much for putting all this together!

scarlet · 09-14-2004, 02:53 PM

Wow! What a fabolous page. I am gonna look into supplementing with calcium and vitamin D.

charitetata · 09-14-2004, 04:46 PM

I was pondering the yeast connection to PCOS and my nutritionist has suggested many of Marykate's offerings as well as thinks there might be a correlation between them for some people. so this is my input
I am currently on a yeast free/wheat free diet along with multivitamins super milk thistle yeast fighters and cal-d glucarate
and I have lost 7 lbs in less than 1 month, getting my energy back and I have had a period every month (i was on sporanax for mold allergies but my ENT took me off and started me on the yeast/wheat free diet.) Maybe this is a connection- yeast causes improper glucose breakdown as well as improper nutrient digestion in intestines and cells leading to pcos, possibly or at least a major factor.
just a bit of brainstorming (which is more than most dr's are doing) not meant to be bitter sounding

JenJohn2001 · 03-07-2005, 11:55 PM

Please forgive me but I do not have an attention span or patience level to read your website and understand it clearly. What I did want to clarify is that in your "things to avoid" section, you mentioned bcp's and metformin.
Thise 2 medications are the only things I am on and I am confused and maybe scared now that I should be avoiding both?
I want to stop taking the bcp's because they make my breasts tender and am seeking a possible healthy approach to balancing out my hormones better. Any suggestions?
Thanks

Dreaming Wolf · 06-16-2005, 09:54 AM

I'd just like to point out that I work as a proofreader for a medical journal, and have read less thorough reviews of research, in a similar format, that have been published in scientific journals. So well done!

canistars · 08-03-2005, 12:17 AM

Awesome Thank you!Thanks MaryKate!

moonchiald · 08-10-2005, 04:02 PM

Fabulous work!

Have you read about Salacia Oblonga? I found this herb a few days ago on google.

moonchiald · 08-10-2005, 04:08 PM

As to the yeast comment... I had horrible horrible allergy and sinus problems and after years of the Dr not being able to find out what was wrong my mother bought me the book the yeast connection i read it became convinced that was my problem and found a product called Three-lac. Within a month my problems ceased and I havent had an allergy or sinus problem in over 2 years! If you search this to buy it DONT pay over 49.99 There are independant dist. on this and some charge retail value of somewhere around $65. You can get this on numberous websites including ebay. i had tried other pro-biotics which I am sure you tried as well but none worked anywhere as well as this one did