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Old 12-29-2006, 11:33 AM   #1 (permalink)
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Default Is Met going to help or hurt? I am so confused!

I have been on and off Met for years. In Feb 2006 when I was taking my Met and went to the Dr to have labs done my ALT was 66 and my AST 26. Before that when I was taking Met for longer they were lower than that. Then after that I kinda just forgot about Met and my RE sent me for a full panel of tests before he put me back on the Met and my ALT went up to 100 and my AST went up to 55 and this was Nov 2006. Both my RE and my DR told me to get off Met and they would retest me in Feb 2007. They said the non alc. fatty liver is very common in PCOS. I tried explaining that during that time I was off Met and the only response I got was that if there is something wrong with my liver then Met will make it worse. But I asked if they wanted to do an u/s or something else to look into my liver and neither were concerned and just said to stop the Met. Well now I am just lost since people are posting articles that Met helps with fatty liver and since my liver enzymes were better on Met. I dont know what to do
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Old 12-29-2006, 11:35 AM   #2 (permalink)
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Ask another doctor for a second opinion!
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Old 12-29-2006, 01:52 PM   #3 (permalink)
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Originally Met was thought to cause NAFLD and people with liver troubles were warned against taking Met. It's hard when new studies come out getting a doc who knows about the new studies.

Women with PCOS at Increased Risk for Liver Disease

A unique defect in the regulation of visceral fat cell lipolysis in pcos...IR
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Old 12-29-2006, 02:14 PM   #4 (permalink)
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So now its supposed to help? And I really shouldnt be off Met?
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Old 12-29-2006, 03:05 PM   #5 (permalink)
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Originally Posted by KimberlyHeidi View Post
So now its supposed to help? And I really shouldnt be off Met?
Here is a study done on rats. The Met. helped their liver problems:

http://www.nature.com/nm/journal/v6/...m0900_998.html

Here is a study hopeing to find an association between Met. and better liver function:

http://www.clinicaltrials.gov/ct/show/NCT00303537

More tests on rats where Met helped:

http://jpet.aspetjournals.org/cgi/co...act/316/3/1053

http://www.blackwell-synergy.com/lin...2.00306.x/abs/

One on humans which said Met. helped:

http://diabetes.diabetesjournals.org.../53/8/2169.pdf
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Old 12-29-2006, 05:11 PM   #6 (permalink)
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Thank you for all the studies. So should I print them all out and bring them to both my RE and DR and tell them I want back on Met and then we will check my liver functions again? I dont understand why both were under the impression Met would make it worse..
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Old 12-29-2006, 05:27 PM   #7 (permalink)
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Originally Posted by KimberlyHeidi View Post
Thank you for all the studies. So should I print them all out and bring them to both my RE and DR and tell them I want back on Met and then we will check my liver functions again? I dont understand why both were under the impression Met would make it worse..

Met. is considered by the majority of docs to not be for people with liver problems. Met. is just one of many drugs on the list of meds to avoid if you have liver problems. It can take a long time for a drug to be taken off that list. If you Google Metformin and Liver you will get warning after warning that it's not to be taken if you have liver problems. It has not currently been proven that Met is Ok to take if you have liver problems. Even the company that makes Gluc. says not to take it if you have liver problems:

http://www.diabetesmonitor.com/metf-qa.htm

I would suggest you print out the studies and take them to your docs, but be aware that not all docs are open to studies.
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Old 12-29-2006, 05:29 PM   #8 (permalink)
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Its just so weird bc my liver enzymes were lower when I was on Met and higher when I was off so I would think that would click in the Drs head
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Old 12-29-2006, 05:34 PM   #9 (permalink)
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Its just so weird bc my liver enzymes were lower when I was on Met and higher when I was off so I would think that would click in the Drs head
Sometimes what they have been instructed overrides what they see in the patient's files. My Dad kept getting dehydrated and going unresponsive. Doc after doc declared him minutes from death. That's what they were taught to do. Once hydrated he perked up again and would ask why he was in the hosptial. The docs were pretty embarrassed. Sometimes they just can't see how one patient might need something that goes against current medical reasoning.
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Old 12-29-2006, 06:04 PM   #10 (permalink)
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Its so hard to say anything for sure, because new studies are always coming out and different docs have different opinions. But according to my endo, met is helpfull for a fatty liver, but not meant for people with a liver disease.
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Old 01-30-2007, 08:54 PM   #11 (permalink)
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KimberlyHeidi-What did you ever decide to do? Did you go back to your doc and get back on Met?

I just got some bloodwork in the mail that was done at my cardiologist's (so I doubt he's concerned about my liver) and my AST is 61 and ALT is 70 (both on a scale of 0-40). I don't know if I should call my regular doc (who I know will just tell me to go on a low carb diet and lose weight and that I have metabolic syndrome and am almost diabetic), call my gyno or just not worry about it. My gyno wants me on Met and she never checked my liver before. I have had it checked several times in the past few years and this is the first time enzymes have been high. I do have fatty liver and had an ultrasound on about 1 1/2 years ago and was told it was just fatty liver. I have been on and off Met during that time and they were never high when I was on or off the Met so this makes me think it's getting worse.
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Old 01-31-2007, 12:47 PM   #12 (permalink)
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KimberlyHeidi-What did you ever decide to do? Did you go back to your doc and get back on Met?

I just got some bloodwork in the mail that was done at my cardiologist's (so I doubt he's concerned about my liver) and my AST is 61 and ALT is 70 (both on a scale of 0-40). I don't know if I should call my regular doc (who I know will just tell me to go on a low carb diet and lose weight and that I have metabolic syndrome and am almost diabetic), call my gyno or just not worry about it. My gyno wants me on Met and she never checked my liver before. I have had it checked several times in the past few years and this is the first time enzymes have been high. I do have fatty liver and had an ultrasound on about 1 1/2 years ago and was told it was just fatty liver. I have been on and off Met during that time and they were never high when I was on or off the Met so this makes me think it's getting worse.

DH has FLD and was told to watch his fat intake and avoid certain meds including Tylonol. Both his parents are type 2, so even with FLD I"m going to try to get a doc to put him on Met. He is already showing signs of IR.
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Old 01-31-2007, 05:44 PM   #13 (permalink)
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Default I don't know if this helps...

When I was on metformin, I would get sick pretty often. I would have nausea, vomiting, the works. () I told my doctor about it, she asked if I ever stopped taking it when I got sick. I was honest, I did stop taking it when I got sick. She said that maybe it was because I kept stopping and starting the medicine that I got sick. However, it got to the point where I was sick every day for almost two weeks. I stopped taking it altogether.

Honestly, my blood sugar has been under control through diet and exercise, and I see no drastic difference when i'm on the metformin. Maybe it's just me.

I don't know if this helps you, but be aware that the metformin can have negative side effects if you keep stopping/starting it. There are other medicines available if blood sugar is your main concern.
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