 Met Therapy Increases Release of D-Chiro-Inositol in Women with PCOS (New Study!)
Metformin Therapy Increases Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator in Women with Polycystic Ovary Syndrome
Some actions of insulin are mediated by putative inositolphosphoglycan mediators, and a deficiency in D-chiro-inositol-containing inositolphosphoglycan (DCI-IPG) may contribute to insulin resistance in women with polycystic ovary syndrome (PCOS). Furthermore, similar effects of DCI and metformin, an insulin-sensitizing drug, have been demonstrated in PCOS women. To determine whether metformin improves insulin actions by increasing biologically active DCI-IPG in women with PCOS, we analyzed DCI-IPG during an oral glucose tolerance test in 19 obese women with PCOS before and after 4–8 wk of metformin or placebo. After treatment, the mean (±SE) area under the curve (AUC) during the oral glucose tolerance test of insulin (AUCinsulin) decreased significantly more in the metformin group, compared with the placebo group [-3574 ± 962 vs. +1367 ± 1021 µIU/min·ml (-26 ± 7 vs. +10 ± 7 nmol/min·liter), P = 0.003], but the AUC of DCI-IPG (AUCDCI-IPG) decreased similarly in both groups (-1452 ± 968 vs. -2207 ± 1021%/min, P = 0.60). However, the ratio of AUCDCI-IPG/AUCinsulin increased by 160% after metformin and decreased by 29% after placebo (P = 0.002 between groups). Moreover, metformin seemed to improve the positive correlation between AUCDCI-IPG and AUCinsulin but not placebo (r = 0.32, P = 0.68 at baseline; r = 0.52, P = 0.12 after metformin; and r = -0.39, P = 0.30 after placebo). We conclude that in obese women with PCOS, metformin may improve the action of insulin in part by improving insulin-mediated release of DCI-IPG mediators, as evidenced by increased bioactive DCI-IPG released per unit of insulin.
This work was supported in part by National Institutes of Health Grants R01HD35629 and K24HD40237 (both to J.E.N.) and grants from the Fond de Recherche en Santé du Québec (to J.-P.B.). http://jcem.endojournals.org/cgi/con...tract/89/1/242
Linda
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dx pcos 1984, type II diabetes 2001, also hypertension
Met 2000mg since 2001, started Glucophage XR 4/22/04, then switched to Met ER 6/04; also: multi, Vit. C, Vit. E, B12/folic acid combo, fish oil & borage oil combo, garlic capsules, cinnamon, Vitex, calcium with magnesium/zinc, biotin, CoQ10, selenium,iron
Other meds: Verapamil and Altace(for blood pressure)
Started laser hair removal 7/29/03, completed 3/04 (it works!)
UAE for fibroid 3/24/03 and 3/16/04 | 
