I am wondering if you tested negative for IR, did your RE put you on met. If so, did it work? I am trying to determine if I should push my RE for it, since she doesn't typically prescribe it if you tested negative for IR. I read mixed reviews as to whether we should still be on it or not. At this point I'm thinking it can't hurt, but any experience is very welcome!
Thanks!
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I haven't been formally tested for ir. My fasting glucose was normal but my dr said she'll put me on met when I see her next week if I would like it. I've looked into it a bit and have found references to normal insulin sensitivity in muscles of some pcos women with hypersensitive ovaries. Which makes me think it's worth trying met.
here are two studies that talk about different levels of insulin sensitivity in muscle vs ovaries were done in cell cultures (pmid 8530637) and homogenized ovary tissue (pmid 6382082). If you google pmid and the number you should be able to find the papers which you could show your dr
Last edited by Thermophile; 11-06-2009 at 02:59 AM.
I am wondering if you tested negative for IR, did your RE put you on met. If so, did it work? I am trying to determine if I should push my RE for it, since she doesn't typically prescribe it if you tested negative for IR. I read mixed reviews as to whether we should still be on it or not. At this point I'm thinking it can't hurt, but any experience is very welcome!
Thanks!
I dont have IR and was put on 2000mg of met i decided i was just going to take 500mg and my doc didnt mind, i ended up losing 60 pounds and had regular periods for the first time!!!
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I'm a microbial ecologist (oh THAT kind of dr ) if you'd told me two months ago that I'd be attempting to read endocrinology papers in the evening, I would have asked for a hit of whatever you were smoking
Thermophile--my PhD was actually focused in disease ecology, so not all that different! But yes, now I devour endo texts/articles as my "fun" reading...: ) I just keep reading so many conflicting studies on whether met is actually beneficial or not for non-IR folks, especially those who are thin. Bleh! I have a 2 hr GTT scheduled for next week, so I'll see if that reveals anything.
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jcza. Yeah pretty similar-when I was looking for postdocs last year most of the jobs were in disease or human microbiome ecology. Interesting but I really like playing outside
were you tested for fasting glucose and insulin? I was only tested for glucose-which was normal. And though I was just diagnosed, I'm pretty sure that I've had pcos since I was 19-20. I had a gtt back then that was normal. My provincial health system doesn't do insulin levels (I'm not sure why not but I've decided to try met for a trial period to see if it helps me ovulate)
I've decided to take met because 1) the mechanism for insulin effect on androgens/ovaries isn't very well understood so predicting an individuals response to sensitizing agents can't be predicted very well. 2) I have a huge family history of diabetes-all grandparents, some aunts and uncles... 3)the research that has shown differential insuln sensitivity in ovaries vs muscle tissues so even though I'm not overtly insulin resistant (normal glucose every time I've been tested which has been at least once a year because of my family history) met may work on my ovaries
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Met without IR? 
) if you'd told me two months ago that I'd be attempting to read endocrinology papers in the evening, I would have asked for a hit of whatever you were smoking 
