Metformin administration modulates and restores luteinizing hormone spontaneous episo

lissadell · 01-13-2004, 04:51 PM

Hi all,

Just found this and wanted to share...another study that shows positive effects of Metformin treatment for us thin cysters.

Lissa

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Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome.

Genazzani AD, Battaglia C, Malavasi B, Strucchi C, Tortolani F, Gamba O.

Department of Obstetrics and Gynecology, University of Modena, Modena, Italy

To evaluate the effects of metformin administration on spontaneous LH episodic release in a group of nonobese polycystic ovary (PCOS) patients. Controlled clinical study. PCOS patients in a clinical research environment. Twenty nonobese PCOS patients were enrolled after informed consent. All patients underwent hormonal evaluations and a pulsatility study (sampling every 10 minutes for 4 hours) before and at the sixth month of therapy (metformin, 500 mg, p.o. b.i.d.). Ultrasound examinations and Ferriman-Gallwey scoring were also performed. Measurements of plasma LH, FSH, estradiol (E(2)), androstenedione (A), 17-hydroxy-progesterone (17-OHP), and testosterone (T), glucose, insulin, and C-peptide concentrations. After 6 months of metformin administration, the plasma LH, 17-OHP, A, and T levels and LH/FSH ratio were significantly reduced. Insulin sensitivity, expressed as the glucose-to-insulin ratio, was significantly improved under glucose load after 6 months of treatment. Spontaneous LH episodic release showed a significant reduction in pulse amplitude with no changes in pulse frequency. Menstrual cyclicity was restored in all amenorrheic and oligomenorrheic women. The ovarian volume and Ferriman-Gallwey scores also were significantly reduced. Metformin administration improves reproductive axis functioning in hyperandrogenic nonobese PCOS patients. By acting on the ovary and restoring normal ovarian activity, metformin positively modulates the reproductive axis (namely GnRH-LH episodic release).

http://www.docguide.com/news/content...256DFC00808470

waiting for first · 01-14-2004, 11:18 AM

Thanks for posting this encouraging study

Beth

Doobie · 01-14-2004, 08:47 PM

Thank you for posting this. If DCI doesn't work for me, I'm going to give Met a try. This article should help me get over through to the uneducated Endo that I saw last june. He was of the "you're not overweight, so you don't need met" camp.