I don't think caffeine and met react bad per say... (persay?) but caffeine is thought to increase/cause insulin resistance. I have read various things over the years pointing to caffeine and aspartame being bad, bad, bad from an IR point of view yet I am a professed diet coke junkie and I CANNOT seem to give the stuff up. Well COULD not. I keep trying... and I'll go a while... but then I fall of the wagon. I am talking I start my day with 2 litres of diet coke instead of breakfast. And the day snowballs from there. I am high as a kite through mid afternoon and then I crash and start craving sugary carby stuff. Then I start grazing and have no interest in a healthy dinner. But then I spend the rest of the evening grazing. And I know it's bad but it's like I need that kick to start my day, to get me in a good mood... Honestly? To a degree I think I am self-medicating for depression. Of course it's a chicken or egg thing because caffeine withdrawl makes you moody so do I drink caffeine because I am depressed or am I depressed because I drink caffeine? (Or need to?)
Here is one article I found on caffeine and IR:
http://www.cbc.ca/story/science/national/2002/01/09/caffeine_diabetes020109.html
I hope that link works. I look for stuff like this all the time to scare myself straight...
I have also read that caffeine significantly increases adrenal output and adrenal hormones contribute to our problems as well.
ANYWAY I go on and off the wagon. I go off caffeine for a few weeks... the first day I get a headache, sometimes a migraine, towards evening. The first 3 days I feel kind of lethargic. Then it's like my natural energy abilities come back and I am OK. But for some reason or other I get near 3 weeks and I crave it again and I cave, think "One day won't hurt" but one day somehow becomes 2 months and I hate myself for being addicted. (And it seems like such a lame addiction... cocaine, cigarettes, at least those seem like normal, understandable addictions... diet coke just sounds like well why don't you just give it up? But caffeine supposedly is one of the most addictive substances there is...)
The longest I hav e ever gone without since getting hooked was 10 months or so while I was pregnant and then when I was first nursing... but then I started again and it didn't seem to affect the baby so I kept going. Ugh.
So now I am trying again and I am on my 15th caffeine free day here - and I am also on antidepressants this time around and that seems to be making a HUGE difference in my attitude towards this. I hope I can make it to 3 weeks and keep going. One of the best things about being off caffeine (aside from being free of the embarrassment of having 10 or more diet coke bottles in the recylcing bin at the curb every week) is that my craving for junk food goes way, way down and I am much more able to stick to a healthy way of eating. Plus I actually eat breakfast which has its own benefits.
ANYWAY back to your original question, why not met and caffeine... I think that if you over do caffeine, you're cancelling out the effects of the met. It's like you're simultaniuosly taking something to make your IR better and something to make your IR worse. There are probably safe limits, say, a can or two of pop a day won't hurt you or won't hurt you much - but I personally have to do all or nothing. So it's easier for me to abstain.