LeeDawson

Monday 30 April 2007

Metformin effective CC alternative for women with PCOS
Source: Fertility and Sterility 2007; Advance online publication

Looking at alternatives to clomiphene citrate treatment for women with polycystic ovary syndrome.

Experts have identified a drug that can effectively treat women with polycystic ovary syndrome (PCOS) who are resistant to clomiphene citrate (CC) therapy.

Almost a quarter of all women with PCOS fail to ovulate in response to CC treatment.

In the search for alternative drugs, recent attention has turned to those with insulin-sensitizing actions, such as metformin and N-acetyl cysteine.

Aboubakr Elnashar (Benha University Hospital) and team found that of these two drugs, only metformin effectively induced ovulation in women with PCOS who resisted CC treatment.

Sixty-one infertile women with PCOS were assigned to either 1500 mg/day metformin or 1.8 g/day N-acetyl cysteine, for 6 weeks.

Women receiving metformin experienced a significant decrease in fasting glucose and fasting insulin levels while women in the N-acetyl cysteine group experienced no such effects.

Ovulation was significantly better in women who took metformin, at 51.6 percent compared with 6.7 percent in those who took N-acetyl cysteine.

The scientists conclude: "Metformin alone is an effective drug for inducing ovulation in CC-resistant PCOS, whereas N-acetyl cysteine alone is not.

"N-Acetyl cysteine may be an adjuvant to CC, but not an alternative."

Posted: 07 March 2007

© 2007 Current Medicine Group Ltd, a part of Springer Science+Business Media


http://www.orgyn.com/en/news/2007/We...effective_.asp

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navy_wife_martin

interesting! and a real boost. thanks for posting.

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Rena
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Vance

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JessicaStillman

I have been on Metformin for a year, but a lower dosage, I have not had any luck on that, it could just be me, but the study does look promising, i will be talking to my doctor about upping the dosage, thanks

Future Doc Cyster

Thank you, Lee, for posting this article! I love reading about new research related to PCOS!

The ladies on this site are great about keeping one another informed!

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**~Future Doc Cyster~**

1500mg Met
Yasmin
Mama to 1 furbaby, Maya, the Toy Poodle/Maltese
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LeeDawson

your very welcome!
I hope that infomation will help!

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phoebe_33

This is great! Hardly anyone I've spoken to knows anything about NAC and PCOS. I was pretty sure it made me feel a bit better, but it's so expensive here so I stopped buying it. I'm on met - waiting for it to work! But great to feel like I'm not throwing away my chance to health by not keeping up with NAC. It did make a difference though, for sure.

adorabelle

Interesting, great article!