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Old 09-06-2009, 10:42 PM   #1 (permalink)
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Default Metformin question-need your insight

Hi ladies! I was put on MET 500mg 2x/day on May 11. On May 21st I started AF (I hadn't had a period since Jan 11). I bled for 14 days. During this cycle I temped and used fertility friend to keep track. I got solid crosshairs on cd18 indicating I had O'd. on cd 36 (FF said I should get AF by this date), I had spotting, for 4 days, but not a full blown period. I had a little more spotting a few weeks later, but that was it.

In the beginning of Aug, I had my 3 month follow up blood work. Results came back and my Insulin and testosterone levels were still up. So OB put me on 1000mg 2x/day. I started this dosage on Aug 29th and 7 days later I got AF. It's not really heavy, but way more than spotting.

So my questions are....
1. Do you think that both of these instances of AF are coincidentaland have nothing to do with the MET? and....

2. What is it about Met that would make me get AF? I thought that the reason AF arrives is because progesterone levels are up after ovulation, then drop and bring on the shedding of the lining if implantation didn't occur.

I'm just confused because obviously I didn't ovulate either of the 2 times I started AF after being on MET originally and then when they upp'ed my dosage.

Sorry this is long....any insight would be awesome!
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Old 09-07-2009, 02:45 PM   #2 (permalink)
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Default

Firstly you can get AF without ovulating, and yes you are right that its the progesterone levels lowering that cause AF.

Metformin works by decreasing your insulin resistance which in turn lowers your testosterone levels and allowing the levels of your female hormones to increase and be detected by your body more normally. This regulates your cycles and hopefully the presence of the correct horomones will cause you to ovulate and have normal cycles. But this doesnt work for everyone. It is possible the orginal doseage wasnt high enough to cure the insulin resistance and this doseage might help.

I think the met did have something to do with getting AF because it allowed your bodies receptors to work as it should

HTH somehow

lizzie xxx
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DX - PCOS April 2008, US March 2009, PCOS confirmed, Refered to endo next appointment 25/02/2010
TX - Metformin 1700 mgs but starting off on 500 mgs. Mefanamic Acid

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