I looked in my drug book for Spiro it says this: if taken with certain other drugs it could increase, decrease, or alter the effects of it. As in nonsteroidal anti-inflammatory drugs such as Advil, Aleve, and Motrin(ibprofen). It didn't say anything about aspirin so I am not sure. I don't think Motrin cold and sinus has aspirin. I would call your pham. and ask them what they think about you taking this or even you Dr. I don't know if this helps you out or not
