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07-24-2008, 10:04 AM
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#1 (permalink)
| | Registered User
Join Date: Nov 2006 Location: Cairo, Egypt
Posts: 141
Points: 2,359.28 Bank: 16,319,242.37 Total Points: 16,321,601.65 |  New Drug for PCOS?
Hey Ladies...
I recieved the following info on my email today and wud like to share it... 1) New Drug for PCOS?
If you're into taking prescription drugs to manage
your PCOS, you'll want to read this.
Have you heard of "naltrexone"? It is a drug used
primarily to treat drug and alcohol addiction. But in
low doses, some clinicians have been using
naltrexone as an "off label" treatment for AIDS,
cancer, autoimmune diseases and central nervous
system disorders.
The first report of using naltrexone for PCOS has
just been released.
Thirty women with PCOS and infertility were
treated with naltrexone for 6 months. In addition
to improved pregnancy rates, naltrexone was
shown to be helpful for wei.ght loss, and reductions
in insulin and testosterone levels. It also improved
LH/follicle-stimulating hormone ratio. All of these
factors are problem areas in PCOS.
Should you take naltrexone?
Read the full article here. www.ovarian-cysts-pcos.com/news62.html
__________________
-Married since 11/05
-me-31 husband-34
-Thin cyster
-dx 1 yr before marriage after a long journey of stupid gynos
-got pregnant naturally 1 month and half after marriage
-m/c after 11weeks
-tried metformin 1500mgs for 6 months made me loose too much weight and no progress | 
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07-24-2008, 10:25 AM
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#2 (permalink)
| | GO WINGS!
Join Date: Feb 2006 Location: Somewhere inbetween insanity and bliss!
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Interesting. Can I ask who sent the email?
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Jenny
~Carl's Wife 4-18-98
Mommy to CJ 6-21 -99 and Emily 2-23-07 BOTH ARE MIRACLES!
DX 2000, Metformin Battle 2500 MG
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07-24-2008, 11:13 AM
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#3 (permalink)
| | Registered User
Join Date: Nov 2002
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Glad the op posted this!  I must not have gotten my newsletter this month or I accidentally deleted it. It is from Nancy Dunne, N.D. her site sends out email newsletters if you sign up for them.
Here is another link to the newsletter http://www.ovarian-cysts-pcos.com/news62.html
Here is a link to the study they mention in the newsletter/on their site http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum | |
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07-24-2008, 12:02 PM
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#4 (permalink)
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Here is an older article on this subject --
Article: Heroin addiction drug could help fertility
June 25, 2004 - 4:13PM http://www.smh.com.au/articles/2004/...046279813.html Quote:
Perth woman Jodie Gaywood had been told she could not ovulate because of [b]Polycystic Ovary Syndrome (PCOS)[b], and had been turned down for adoption.
However, after receiving an implant of naltrexone, Mrs Gaywood is now pregnant.
Obstetrician Dr George O'Neil, who also treats patients for heroin addiction, said he hit on the idea of using naltrexone to treat infertility after seeing more than 50 of his heroin patients become pregnant.
| . . . . . Quote: It works on the same receptors to help women to ovulate
"When you have a fright or are stressed or you do something that's really pleasurable you release a lot of your own opiates, and we know that people don't get pregnant if they're stressed," Dr O'Neil explained.
"If you block the opiates you can get the part of the brain known as the hypothalamus to start working better, then the pituitary gland starts to work better, and as a result the ovaries start to work better.
"When the ovaries start to work better they go back to releasing eggs normally."
Women with PCOS and those who fail to ovulate could benefit from naltrexone, which Dr O'Neil plans to start formally testing as a fertility treatment.
"There are a large number of people who have PCOS and normally they'd be treated ... with a fertility drug that makes the ovary produce more eggs, or they'd be treated by drilling small holes in the ovary," Dr O'Neil said.
"This approach would potentially be another way of helping them ovulate."
Naltrexone costs about the same amount as existing fertility treatments, and Dr O'Neil is confident it would have no more side effects than other fertility drugs.
| . . . . . Quote:
Although little research has been conducted on the effect of naltrexone on unborn babies, he said he had not seen any adverse outcomes in babies whose mothers took naltrexone for heroin addiction.
"As far as we know, with the 50 or more children we've seen delivered with naltrexone in Perth, they all appear to be doing very well," Dr O'Neil said. | | |
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07-24-2008, 12:22 PM
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#5 (permalink)
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I find this stuff about the opiates fascinating. I wonder if the reason acupuncture works for fertility problems is related to this? I think I read that acupuncture does have some sort of effects on the body's natural opiates. | |
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07-24-2008, 12:43 PM
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#6 (permalink)
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just a heads up my dad is an alcoholic and has had naltrexone and it gave awful side effects even on the low dose. Also like most drugs as soon as u come off it the old effects come back again this will be the same for PCOS. U wont b able to drink alcohol at ALL as u WILL b violently sick and i mean violently its no joke. So if it becomes a recognised drug for pcos dont just jump into go through it with a fine tooth comb with ur doctor as its not a drug to be messed with !!!!
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07-24-2008, 01:27 PM
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#7 (permalink)
| | silly/cheerful DC cyster
Join Date: Jun 2005 Location: Capital Heights MD
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Quote:
Originally Posted by zillie  just a heads up my dad is an alcoholic and has had naltrexone and it gave awful side effects even on the low dose. Also like most drugs as soon as u come off it the old effects come back again this will be the same for PCOS. U wont b able to drink alcohol at ALL as u WILL b violently sick and i mean violently its no joke. So if it becomes a recognised drug for pcos dont just jump into go through it with a fine tooth comb with ur doctor as its not a drug to be messed with !!!! | Interesting. I was thinking of calling my Dr and asking for it. Im going to go online and look up more stuff about it.
__________________ ___________________ Mekhi Josiah (14m) 7/18/07 Kei 28 - Reggie 33
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"But you be strong and do not lose courage, for there is reward for your work" (2 Chronicles 15:7) | |
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07-24-2008, 01:39 PM
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#8 (permalink)
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Very, very interesting. I will try to read more on it.
__________________ ~First Clomid Cycle~
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07-24-2008, 02:40 PM
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#9 (permalink)
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Join Date: Jul 2008 Location: Melbourne, FL
Posts: 58
My Mood: Points: 1,973.73 Bank: 0.00 Total Points: 1,973.73 | small doses
when you say small doses, currently it comes in doses of 50 mg that is used for alcoholics and herion addicts, for PCOS they are talking 1.5-3mg in fact i have found out that the makers only make it in 50 mg and only certian pharmicies basically crush it down and make it into 1.5mg pills, do you know how much your father was taking, i have been researching this, and i actually have been finding very few side effects with that low of a dose. | |
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07-24-2008, 05:25 PM
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#10 (permalink)
| | silly/cheerful DC cyster
Join Date: Jun 2005 Location: Capital Heights MD
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Quote:
Originally Posted by dkim1986 when you say small doses, currently it comes in doses of 50 mg that is used for alcoholics and herion addicts, for PCOS they are talking 1.5-3mg in fact i have found out that the makers only make it in 50 mg and only certian pharmicies basically crush it down and make it into 1.5mg pills, do you know how much your father was taking, i have been researching this, and i actually have been finding very few side effects with that low of a dose. | I am also back from my online research and it seems that vomiting is more common when alcholics take the medication. But for its off label uses it seems that the side effects are small.
It does have some indication that it can cause Liver damage in high doses. Dont know how it affect babies either.
__________________ ___________________ Mekhi Josiah (14m) 7/18/07 Kei 28 - Reggie 33
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"But you be strong and do not lose courage, for there is reward for your work" (2 Chronicles 15:7) | |
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07-25-2008, 11:46 AM
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#11 (permalink)
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I have a friend taking LDN. He takes 4.5mg before bed, and aside for some pretty psychadelic dreams, he has had no side effects.
He gets it in a powder form (250mg bottle) and mixes it with water, then drinks 4.5 ml before bed. He has been suggesting it to me for a long time, I've just been waiting for more information to become available in regards to PCOS patients using it! I'm going to start taking it next week....I'll keep you guys posted! 
__________________ *****marymary***** "No one conquers who doesn't fight" Me - 27 DH - 28 Married 11/05/07 at sea!!
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symptoms since 1996, finally "officially" diagnosed 2008. Medications: Yaz, tried Metformin...not a fan! Planning to start TTC this fall/winter!!! To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts. | |
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07-25-2008, 01:24 PM
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#12 (permalink)
| | HottMommA
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ive been hearing about it, i need to research it more.
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Battling pcos 9 years
recently started herbal teas, AF has returned!
using:
Womens Liberty, Female Toner, Saw Palmetto, False Unicorn Root, Black Cohosh, Black Chai, Milk Thistle, Detox
JOIN GROUP: UPLIFTING AND SENSE OF HUMOR CYSTERS/*MARRIED CYSTERS*
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07-25-2008, 04:12 PM
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#13 (permalink)
| | silly/cheerful DC cyster
Join Date: Jun 2005 Location: Capital Heights MD
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Quote:
Originally Posted by marybug I have a friend taking LDN. He takes 4.5mg before bed, and aside for some pretty psychadelic dreams, he has had no side effects.
He gets it in a powder form (250mg bottle) and mixes it with water, then drinks 4.5 ml before bed. He has been suggesting it to me for a long time, I've just been waiting for more information to become available in regards to PCOS patients using it! I'm going to start taking it next week....I'll keep you guys posted! |
Did your OBGYN give you a perscription for it?
__________________ ___________________ Mekhi Josiah (14m) 7/18/07 Kei 28 - Reggie 33
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07-25-2008, 04:53 PM
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#15 (permalink)
| | Praying for Baby #1.
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This is all really interesting.
I am anxious to see what your doctor says about all that. Please let us know.
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Jenn
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Working on getting healthy
Re-Starting fertility treatments in Jan 09"
Currently on 1500mg of Metformin.
Here is to a Healthier new ME!
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