jjely44

I have been on Met for about 2 months - the 1st month I was building up to full dosage. So I have been on 1500 mg for about 4 weeks. I have not ovulated and am getting frustrated. All the research I have read has said how good the success rates were - between 80-90 percent. It would be just my luck to be the 10 % that does not ovulate.

I am also finding it hard to remeber to take 3 pills a day - I normally take them all within 6-8 hours - afternoon thru evening. Is there a major difference between the XR and the regular metformin?

I also wonder how effective metformin is for people who are not typical PCOS - I don't have excess hair and am not overweight, but I do have immature follicles and an off LH:FSH level. Anyone have any info about this?

Thanks
Jodi

JulieC

Hang in there ... it can take up to 6 months to see the full effects of the metformin. I'm thin (err, was thin, hehe!), mild extra-hair, 70 day cycles. Met got my cycles down to 36 days right away, but with only wimpy O's. I O'd pretty well on met+Clomid and on met+Gonal-F which was my magic combo

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waiting for first

Yep, it can take 6 months to see if the met really is working, and you also may need to up your dosage over time. Many docs prefer regular met to the XR because that is what most of the research has been done on...the regular. Although, I've heard of some people asking for the XR if regular hasn't worked for them (ditto for requesting glucophage vs. metformin...some people swear one works better for them than the other).

I was like you...I low carbed for a while when ttc, then went on metformin 1500 mg, built up my dose for about 3 weeks. We added clomid (I had already done several other clomid cycles that never made me O) and I still didn't O. I was given the option to wait out the met/clomid or move onto injectables, and I opted for the latter as I hadn't O'd in 8 months of ttc at that point. I was ready for gonal F. I did eventually conceive on the gonal F (2nd cycle, but it was the first ovulatory one since I overstimmed and was cancelled my 1st cycle). I'm curious if met wouid have worked if I stayed on it w/ clomid longer, but I never regretted moving onto injectables. I stayed on met through my first trimester.

It may take some time. You may need to have your doc play w/ the dose. Hang in there, and I hope it works for you

beth

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