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Press Release Source: Nutrition 21, Inc.

New Study Shows Chromium Picolinate and Biotin Combination Significantly Reduces Fasting Blood Glucose in People with Type 2 Diabetes
Monday June 7, 9:31 am ET
Results From Diachrome(TM) Clinical Trial Presented at American Diabetes Association Scientific Sessions


ORLANDO, Fla., June 7 /PRNewswire-FirstCall/ -- (Nutrition 21, Inc. Nasdaq: NXXI) -- Results from a new human clinical trial show that daily nutritional supplementation with a combination of chromium picolinate and biotin (marketed as Diachrome) significantly reduced fasting blood glucose levels in patients who had type 2 diabetes for at least one year. The results, which evaluated 25 people over 30 days, were presented today at the American Diabetes Association (ADA) 64th Annual Scientific Sessions in Orlando.
The new randomized, double-blind, placebo-controlled trial found significant improvements in blood sugar control in patients who had baseline post-prandial blood glucose (PBG) levels above 200 mg/dL, and HbA1c levels greater than or equal to 7% and added Diachrome to their diabetes treatment regimen:

* Fasting Blood Glucose (FBG) levels significantly decreased by an average of 26.2 mg/dL; the significant drop was observed in over 70% of subjects taking Diachrome, compared with just 27% in the placebo group (p < 0.01).

* Fructosamine Levels showed a mean decrease in the subjects taking Diachrome of -32.4 micron M/L, while placebo group levels increased by +7.73 micorn M/L. The difference between groups approached
significance (p< 0.07), and therefore warrants further study. The fructosamine test provides a measure of average blood glucose levels over several weeks, offering an additional tool to evaluate ongoing treatment effectiveness.


"These results indicate that Diachrome should be considered a valuable adjunct therapy for type 2 diabetes patients whose blood sugar levels are not tightly controlled through oral anti-hyperglycemic medications and/or diet and exercise," states Jeffrey Geohas, MD, principal investigator, medical director, Radiant Research, Inc., Chicago. "Diachrome shows effectiveness in improving two important measures of ongoing blood glucose control."

According to Anne Daly, MS, RD, BC-ADM, CDE, leading author and expert in diabetes care and education, "Maintaining tight blood sugar control helps reduce the risk of long-term complications often associated with diabetes, and improves quality of life for patients." Daily adds, "The evidence supports Diachrome as a nutritional therapy that is not only safe and effective, but also affordable and convenient to use."

Additional data from the trial were reported on May 6th at an American Heart Association conference. The study found that Diachrome supplementation also provided significant improvement in coronary risk factors, including total cholesterol levels, LDL ("bad") cholesterol levels and lipid ratios.

"These outcomes indicate that Diachrome can have dramatic short term health benefits that could lead to improved and more affordable patient care," said Gail Montgomery, President and CEO of Nutrition 21, the company that contracted the study. "Over the coming months, we hope to bring forward a conclusive body of evidence that will encourage the healthcare community to adopt Diachrome as a standard nutrient therapy in diabetes care."

There are 18.2 million people in the United States who have diabetes. Complications of poor blood glucose control in people with type 2 diabetes, include heart disease and stroke, blindness, nerve damage, kidney damage and amputation.

About Nutrition 21

Nutrition 21 is a nutrition bioscience company, which develops and markets nutritional products, with health benefits substantiated by clinical research. The Company markets Chromax, the leading brand of chromium, and holds 35 patents for nutrition products, 22 for chromium compounds and their uses. For more information, visit http://www.nutrition21.com or http://www.diachrome.com or call 1-866-DIACHROME.

Nutrition 21 commissioned the study through Radiant Research, Inc. The results were presented as part of an ADA conference session on nutrition and diabetes, by Manley Finch, Associate Director Clinical Research at Nutrition 21, Inc.

http://biz.yahoo.com/prnews/040607/nym045_1.html

__________________
dx pcos 1984, type II diabetes 2001, also hypertension
Met 2000mg since 2001, started Glucophage XR 4/22/04, then switched to Met ER 6/04; also: multi, Vit. C, Vit. E, B12/folic acid combo, fish oil & borage oil combo, garlic capsules, cinnamon, Vitex, calcium with magnesium/zinc, biotin, CoQ10, selenium,iron
Other meds: Verapamil and Altace(for blood pressure)
Started laser hair removal 7/29/03, completed 3/04 (it works!)
UAE for fibroid 3/24/03 and 3/16/04

Auntlee

I've been taking chromium & biotin (not the brand in that study, just regular vitamins) for about two months now and have really noticed a difference.

I've *always* had to have a snack late morning no matter what I had for breakfast -- *always* had stuff in my desk at work ready for it, and after a month or so I noticed I wasn't hungry for a snack late morning.

What started me thinking I was IR was that after awhile on Atkins I noticed that even a very small amount of certain high glycemic foods -- like corn or anything with corn syrup -- made me sorta drunk -- dizzy for a good 15 minutes.

After a couple months on the chromium/bioton, tho, I don't get that dizzy hit from high glycemic stuff. Haven't lost more weight yet, mostly because I keep "checking" to see if certain foods will make me high. Gotta stop that.

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Aunt Lee


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PersianGirl

I have a question about the drunkness feeling....Was the feeling kind of like you wanted to go to sleep and you could not concentrate on anything....and then all of a sudden it's gone. If this is it...I had that experience today while I was at work...I had a huge craving for something sweet and I noticed afterward I could barely stay awake and I was somewhat moody...I think this all related to this aweful little thing we deal with called PCOS URGH!!!!

Auntlee

Hi,

Nope -- this is different -- this is an instant spike that makes me woozy as soon as I taste the food.

What you're describing sounds more like what happens when you eat too many carbs at one sitting -- that used to happen to me, too, before I started low-carbing.

Insulin resistance is often associated with PCOS -- you might want to have a glucose tolerance test and see if you're insulin resistant.

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Aunt Lee


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