New, thin, and metformin ....

wendi · 04-17-2005, 04:49 PM

Hi! I am new here and wanted to share some information that I have recently found. Not sure if it will be helpful for anyone but we are giving it a try. I am thin, clomid-resistant with no IR issues ... I have tried clomid, and unsuccessfully tried IUI/injectibles (gonal) 5 times but I just produce too many follicles. My husband is a medical student and when our doctor said it was time for IVF, he wanted to investigate a little. Well, he found a bunch of information on metformin and PCOS.

You guys may have no need of this stuff but this is really recent information. My husband talked to an endocrinologist at Mayo who thought a trial with this sounded good. We got my RE to buy into it even though it isn't common practice and I am taking 2000 mg. of metformin and then going to use prometrium (to get a period if I don't on my own) and clomid to see if we can get ovulation since that is our only issue. I am pretty sick from this stuff but it appears to be getting better.

Maybe these articles will help someone? I am excited for this site and hope I can stick around!

Wendi

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=154827 65&dopt=Abstract

http://www.obgynsurvey.com/pt/re/obgynsurv/abstract.00006254-200503000-00020.htm;jsessionid=CjmruZ1qnmWJlPfACMKkfELsb3hGg MhsYwhsoLKLzuj9Yu0yhhe6!-62745742!-949856032!9001!-1

http://www.lef.org/news/LefDailyNews.htm?NewsID=1974&Section=NUTRITION

http://www.findarticles.com/p/articles/mi_m0689/is_2_54/ai_n10299300

http://humrep.oupjournals.org/cgi/content/short/deh580v1

Alchik · 04-18-2005, 02:42 PM

Wendi,
None of these links work...
Maybe they are all expired.
I would love some more info on this.
Please if you get a chance, repost them.

Thanx

wendi · 04-18-2005, 02:59 PM

Okay -- I think I fixed them ... the second one you may need to paste? Not sure what happened the first time.

Alchik · 04-18-2005, 04:08 PM

Thanks,
I'm printing this out right now to show my doc.

Alchik · 05-20-2005, 02:41 PM

Wendi,
I wanted to thank you for these links and let you know that I got Met and I'm up to 1000mg/day. So now I'm just waiting for it to work (ie make me O and shorten my cycles).
Thanx again,
How are you doing?
Any progress? I heard it takes met a while to work, my fingers are still crossed for you.
:-)

BB2003 · 05-20-2005, 11:20 PM

Hey - I am just like you. I was about average size, not IR, and clomid resistant.

We did ovarian drilling and I was pregnant two weeks later after trying two years. Yall might need to look into that as insurance pays for it. It is considered a treatment for PCOS. You would need to get the codes and check for sure - you probably know that. Ovarian drilling has a 60% success rate in the first year and 80% success rate in the following year.

Met never really helped me. I would be hesitant about doing too much clomid. I have no idea how much you have taken and I know your DH is a medical student and probably pretty savvy. I took 7 rounds of clomid and I don't want to take anymore. I read a study here on the research section that studies several thousand women from 1965 to 1988 that used clomid. It didn't say how much or how long. Just said womn who used higher doeses were at a higher risk. Anyway, the findings said these women were 56% more likely to get ovarian or cervical cancer. If my Dr. ever tries to get me to take it again, I will try and talk him out of it - maybe he will let me go straight to injectibles if I need it with the drilling for subsequent children.