Wednesday 13 June 2007
Obesity affects BP regulation in PCOS
Source: Journal of Clinical Endocrinology and Metabolism 2007; 92: 2141-8
Examining why abnormal blood pressure regulation occurs in young women with polycystic ovary syndrome.
MedWire News: Obesity often accounts for the abnormal blood pressure (BP) regulation seen in young women with polycystic ovary syndrome (PCOS), a case-control study has revealed.
Spanish researchers studied the BP of 36 PCOS patients with a mean age of 24.2 years, and 20 healthy women of a similar age and body mass index (BMI).
Thirteen PCOS patients and eight controls were obese, with a BMI of at least 30 kg/m2.
Although hypertension occurred similarly in both groups, the nocturnal decrease in mean BP was smaller in patients than healthy women, at 12.2 versus 16.5 percent, respectively.
Obesity was linked with office hypertension; increased diastolic and mean office BP; and increased heart rate during the day, night, and over 24 hours regardless of whether or not a woman had PCOS.
Non-dipping nocturnal BP was observed in 62 percent of PCOS patients who were obese compared with just 26 percent of those identified as lean or overweight, and 25 percent of healthy women in the latter two weight categories.
Manuel Luque-Ramírez (Universidad de Alcalá, Madrid) and colleagues conclude that although BP regulation abnormalities are frequent in young women with PCOS they “are mostly related to the frequent association of this syndrome with obesity.”
Posted: 12 June 2007
© 2007 Current Medicine Group Ltd, a part of Springer Science+Business Media
http://www.orgyn.com/en/news/2007/We...92460832291667
Obesity affects BP regulation in PCOS 
