Wednesday 13 July 2005
Obesity does not impair endometrial receptivity
Source: Fertility and Sterility 2005; 83: 1629-34
Researchers evaluate the effect of obesity in endometrial receptivity by studying pregnancy rates after oocyte donation.
Body mass index (BMI) does not appear to influence rates of implantation, pregnancy, or spontaneous miscarriage among recipients of donor eggs, indicating that it has no negative effects on endometrial receptivity, say researchers.
While several studies have shown increased rates of poor pregnancy outcomes after IVF in obese women, the question remains as to the underlying mechanism, note Allison Styne-Gross (Emory University School of Medicine, Atlanta, Georgia, USA) and colleagues. Is it exclusively ovarian, endometrial, or a combination of the two?
To assess the impact of BMI on pregnancy outcome, independent of oocyte development, the group analyzed data for 536 women who underwent a first donor oocyte cycle between 1999 and 2004 at a clinic in New Jersey. Pregnancy outcomes were compared among underweight, normal, overweight, and obese women.
The results revealed no significant differences in implantation rates, ongoing pregnancy rates, or rates of pregnancy loss among patients in each of these BMI groups. These findings held for patients receiving blastocyst and those receiving day 3 embryo transfers.
"Based on this information, we can comfortably counsel our oocyte recipients that elevated BMI will have no direct effect on their implantation rate and ability to sustain a pregnancy," Styne-Gross et al comment.
Posted: 11 July 2005
http://www.obgynworld.com/international/news/2005/Week_28/Day_1/Obesity_does_not_imp.asp 
Obesity does not impair endometrial receptivity 
