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Old 03-30-2006, 04:58 PM   #1 (permalink)
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Hi cysters! =) Maybe you can help me out with this question... I've had strong PCOS symptoms since puberty (was only diagnosed last year), and my mother has it as well. I have a young daughter (toddler age), and I'm obviously concerned that it's been passed down to her. Do you know if there is a test they can run now to tell if she'll be dealing with this later on in life? I'd LOVE to know one way or the other, but am assuming I won't be able to find out for another 12 years or so!
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Old 03-31-2006, 06:05 AM   #2 (permalink)
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According to Dr. Elizabeth Vliet (leading hormone expert), studies have not found a single abnormal gene or chromosome that causes PCOS, but each of the major problems seen in PCOS are individually linked to the presence of abnormal genes: obesity, ovarian dysfunction, hirsutism, insulin resistance.
PCOS definitely runs in families (though some women get it because toxins and diets and medications such as depakote). My cousin has it and my brother has symptoms of insulin resistance and hormonal imbalance.

The best thing you can do is to avoid feeding your daughter soy products (which cause hormonal disruption for the ovaries and thyroid gland), processed foods, foods contaminated by hormones and pesticides (endocrine disruptors), excess sugar/flour, and aspartame and monosodium glutamate (also known as "natural flavor," "hydrolzed protein," caseinate...the list of hidden MSG goes on and on). Aspartame and MSG are endocrine disruptors and excitotoxins - they overstimulate the neurons in the brain and trick the brain into thinking something tastes better. These flavorings have been linked to Alzheimer's, MS, Parkinson's and other neurological problems.

Read Dr. Vliet's books "It's My Ovaries, Stupid" and "The Savvy Woman's Guide to PCOS" for more detailed info.
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Old 03-31-2006, 06:11 AM   #3 (permalink)
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My dr says the same as lilywind - get to an organic, all-natural, balanced diet and feed kids that and the problem may not come up at all. I've been reading about PCOS being a Syndrome X condition that is mainly caused by or exacerbated by our modern, convenient, processed food diet.
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Old 03-31-2006, 03:47 PM   #4 (permalink)
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Quote:
Originally Posted by mj_romo
I've been reading about PCOS being a Syndrome X condition that is mainly caused by or exacerbated by our modern, convenient, processed food diet.
And sedentary lifestyle.
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Old 03-31-2006, 07:01 PM   #5 (permalink)
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Thanks for the replies! I'm a Christian woman, so this is obviously something that I'm praying about. If I can do ANYTHING to save her from all of this, I'm definitely going to do it!
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Old 04-03-2006, 05:42 AM   #6 (permalink)
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my mom had it so did hers. my grandmother was raised on a farm, all natural foods, everything was grown there. so it makes me assume that it is genetic in my family, not chemical/induced. I don't know how many generations it goes back on my mom's side, but each generation only has 2 children and all before they're 22.
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Old 04-03-2006, 08:39 AM   #7 (permalink)
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Quote:
Originally Posted by Manna
Hi cysters! =) Maybe you can help me out with this question... I've had strong PCOS symptoms since puberty (was only diagnosed last year), and my mother has it as well. I have a young daughter (toddler age), and I'm obviously concerned that it's been passed down to her. Do you know if there is a test they can run now to tell if she'll be dealing with this later on in life? I'd LOVE to know one way or the other, but am assuming I won't be able to find out for another 12 years or so!
I believe that my type of PCOS, is genetic. My mother, grandmother, aunts, cousin , sister and now niece (12 yrs. old) all had/have it. We also have a strong family history of Diabetes. I know I tried to get my niece diagnosed sooner, but Doctors said to wait until puberty. I did find some information about a connection between PCOS and Chromosome 19:

August 14, 2002
Women With PCOS, Siblings Have Same Gene Defect
CHICAGO --- Siblings of women with polycystic ovary syndrome (PCOS) have metabolic and hormonal abnormalities that are linked to the same gene defect that causes PCOS, a disorder associated with irregular periods, infertility, excessive body hair and increased risk for diabetes.
These new findings came from the $6 million National Institutes of Health-funded National Centers Program for Infertility Research. The study was led by Northwestern University researcher Andrea Dunaif, M.D., Charles F. Kettering Professor, chief of endocrinology and metabolism and professor of medicine at The Feinberg School of Medicine, and collaborators at Pennsylvania State University and the University of Pennsylvania.
Dunaif and co-investigators believe the location of the PCOS gene mutation is on chromosome 19, near the insulin receptor gene, which plays a key role in allowing insulin to enter cells and metabolize sugar. This marker, called allele 8 of D19S884, was associated with risk factors for diabetes in PCOS women and their brothers.
In recently published studies, approximately 50 percent of the sisters of PCOS women had elevated androgen (so-called "male hormones" that are present in both men and women) levels while the other half of the sisters were unaffected. Of the high-androgen group, half (or 25 percent of the sisters) had PCOS and insulin resistance, while the other 25 percent were insulin resistant but showed no PCOS symptoms and had normal menstrual periods.
The PCOS sisters and those with high androgen levels were more obese than unaffected sisters.
The PCOS brothers also had significantly elevated levels of the androgen DHEAS, which correlated with the high androgen levels in their sisters with PCOS.
These results strongly suggest that the same gene defect is responsible for PCOS and the hormonal abnormalities and other symptoms found in the siblings of PCOS-affected women, but further studies are required, Dunaif said.
PCOS is a complex disorder that affects nearly 10 percent of premenopausal women and is associated with elevated levels of androgens, as well as irregular menstrual periods and reproductive problems. Other symptoms of PCOS include obesity, excess hair on the face and body, male-pattern baldness and severe, chronic acne.
Many women with PCOS are insulin-resistant, a condition that raises the level of insulin circulating in the body and is a precursor to type 2 diabetes. In fact, women with PCOS have seven times the risk of other women for developing adult-onset diabetes, which in turn greatly increases their chance of having cardiovascular disease, stroke and kidney problems. Dunaif’s research also has shown that PCOS is an important risk factor for the adult form of diabetes in teenaged girls.
Dunaif’s co-investigator on the NIH grant is Richard L. Legro, M.D., Pennsylvania State University. Also collaborating on the PCOS gene research are Margrit Urbanek and Ralph Kazer, M.D., professor of obstetrics and gynecology and chief of reproductive endocrinology, The Feinberg School of Medicine, Northwestern University; and Richard S. Spielman and Jerome F. Straus III, University of Pennsylvania. Kazer also is co-director of the PCOS Center at Northwestern.

Also here's a link to the different types of PCOS:
http://www.wdxcyber.com/dxinf001.htm
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