Found the following on the web regarding PABA and fertility:
PABA study shows 75% success rate!
But there is a catch… the study was conducted in 1942. It is reported that 16 women who had fertility problems took 100mg of PABA 4x a day for 3-7 months. 75% became pregnant. The effects of PABA on fertility has not been studied since.
A poster on this forum from around 2004 (Auntlee) posted the following regarding PABA:
Last year, when we were TTC -- Dr. prescribed chlomids to help with estrogen; after chlomids didn't work, I did some research about how to help the body maintain estrogen levels with natural remedies and decided to try boron, PABA, and mega doses of folic acid. I'd read that mega doses of folic acid have an estrogen-like effect on the body, and it's cheap.
Unexpectedly, within just a couple of weeks I noticed a difference in facial hirsutism (which I've had to a pretty serious degree since puberty -- at this point, 30 years -- I inherited my mom's PCOS and my dad's heavy beard, lucky me.)
I was alternating days of taking the boron & the PABA -- decided after some research it must be the boron & stopped taking the PABA, and the hair growth got worse again. So I went to taking PABA & boron & folic acid every day.
After three months on this regimen, the hair is substantially less --
there are more hairs without color, more thin, weaker hairs, and more areas that look absolutely normal.
Couple of caveats -- anyone who is even remotely likely to be anemic should probably check with a doctor before starting mega folic acid -- too much folic acid can hide some of the symptoms of a vitamin B12 deficiency. Other than that, your body pretty much takes what folic acid it wants & discards the rest. I'm not a doctor, but my own doctor said I could continue with the mega, as long as I also kept up my levels of B12.
Other caveat -- I'm in a subset of PCOS -- my ovulation & my periods are absolutely regular; the symptoms I have are hirsutism, terrible teen acne, skin tags, insulin resistance, and infertility that may be linked to PCOS. (didn't marry & start TTC until early forties)
I take 50 - 60 mg of folic acid every day -- around 20 800 mcg pills
three times a day, and sometimes four times. I take half a gram of PABA once a day -- I've recently upped this to half a gram twice a day, which seems to work even better. I change up the dosage of boron, but it's around 3 mg a day.
I also take acidolphus, which is supposed to help the body manage folic acid, but this regimen was working well before I started that. I also low-carb -- no sugar, wheat, potatoes, pasta, etc. -- don't know if that makes any difference.
I have no idea if this would work for anyone else, but wanted to let the group know my experience.
I don't know what it is about this that works, (except that I have read that most PCOS'ers have a folic acid deficiency) but over 30 years I've tried everything, and, with the exception of the laser hair removal (which worked great but it all came back in 18 months), this is the only regimen that's done anything. Plus, this keeps getting better, whereas the laser removal's effects wore off.
Folic acid has been shown to help insulin resistance in one study below:
Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia
E Setola,LD Monti,E Galluccio,A Palloshi,G Fragasso,R Paroni,F Magni,EP Sandoli,P Lucotti,S Costa,I Fermo,M Galli-Kienle,A Origgi,A Margonato, and P Piatti
Cardiovascular and Metabolic Rehabilitation Unit, Rehabilitation and Functional Reeducation Division, Scientific Institute H. San Raffaele, Italy.
OBJECTIVE: The purpose of this study was (a) to study whether a folate and vitamin B12 treatment, aimed at decreasing homocysteine levels, might ameliorate insulin resistance and endothelial dysfunction in patients with metabolic syndrome according to the National Cholesterol Education Program-Adult Treatment Panel-III criteria and (b) to evaluate whether, under these metabolic conditions, there is a relationship between hyperhomocysteinemia and insulin resistance. DESIGN AND METHODS: A double-blind, parallel, identical placebo-drug, randomized study was performed for 2 months in 50 patients. Patients were randomly allocated to two groups. In group 1, patients were treated with diet plus placebo for 2 months. In group 2, patients were treated with diet plus placebo for 1 month, followed by diet plus folic acid (5 mg/day) plus vitamin B12 (500 microg/day) for another month. RESULTS: In group 2, folate treatment significantly decreased homocysteine levels by 27.8% (12.2+/-1.2 vs 8.8+/-0.7 micromol/l; P<0.01). A significant decrement was observed for insulin levels (19.9+/-1.7 vs 14.8+/-1.6 microU/ml; P<0.01) accompanied by a 27% reduction in the homeostasis model assessment levels. A positive relationship was found between the decrement of homocysteine and insulin levels (r=0.60; P<0.002). In parallel, endothelial dysfunction significantly improved in the treated group, since post-ischemic maximal hyperemic vasodilation increased by 29.8% and cGMP by 13.6% while asymmetrical dimethylarginine levels decreased by 21.7%. On the contrary, in group 1 patients, treated with placebo, no changes were shown in any of the variables. CONCLUSIONS: Folate and vitamin B12 treatment improved insulin resistance and endothelial dysfunction, along with decreasing homocysteine levels, in patients with metabolic syndrome, suggesting that folic acid has several beneficial effects on cardiovascular disease risk factors.
Paba 
