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Old 07-02-2004, 06:33 AM   #1 (permalink)
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Hi gilrs

I have been diagnosed with PCOS about 9 years ago but my doctor just said "loose weight and everything will get better". Since then I have been to see a dermatoligist for the acne etc. and he said I think you would benefit from Metaformin but I have never prescribed it and think you should go back to your first doctor. I have pleaded with him and he said when I come back 29 July he will see.

I need you girlies to reply to this so I can print it out to show how many women it has helped. Please can you do this for me as this is the last time I will get the chance to go on it and I want to get my hormone's sorted! my weight is going up and up and I think I have hit the 280 mark. SO PLEASE PLEASE PLEASE. reply to let me know the benefits to help sway him so he will prescribe also the dosage you are all on. Thanks

Love to you all and fairy dust to all that wants it......

Bluedawny
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Old 07-02-2004, 07:53 AM   #2 (permalink)
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Hi Bluedawny!

I'm in Southampton as well. What dr do you go to? Maybe it's a question of swapping dr's as well.

I'm with BUPA, and my Endo prescribed the Metformin the first time. After that I got it through the NHS and my own GP. The Endo's name is Dr Derek Sandeman and he sees people through the NHS as well. Maybe you should get your GP to refer you.

I'll have a look for some Metformin articles and post them here later.

Take care
Dani
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Old 07-02-2004, 10:19 AM   #3 (permalink)
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I suggest you take research articles to your doc to help make your case. There is a lot of info in the sticky at the top of this page, here's the link:

FAQ About Metformin

Here is a summary of research you could take as well:

Benefits of Metformin (Glucophage)
LOWERING OF INSULIN, TESTOSTERONE, AND GLUCOSE LEVELS. Quite a number of studies indicate Glucophage reduces insulin, testosterone and glucose levels -- which reduces acne, hirsutism, abdominal obesity, amenorrhea and other symptoms. In one study conducted at Virginia Commonwealth University, 24 obese PCOS women were given metformin or placebo. The 11 women who received the metformin experienced a reduction in insulin levels, which slowed the activity of an enzyme in the ovaries that stimulates excess production of testosterone. As a result, testosterone levels also dropped.(3)

Glucophage appears to do the same for non-obese PCOS women, according to a study from the University of Medical Sciences in Poznan, Poland. Thirty nine PCOS women were given metformin for 12 weeks. They had improvements in insulin, testosterone, hirsutism and acne. (4)

PREVENTION OR DELAY OF ONSET OF DIABETES. Glucophage may help to prevent diabetes, according to a study at George Washington University.(5) In this study, 3,234 non-diabetics with elevated blood glucose were given metformin, placebo, or lifestyle recommendations. The incidence of diabetes in the metformin group was 31% less than in the placebo group.

RESTORATION OF NORMAL MENSTRUAL CYCLE. A number of studies have shown that menstruation can be restored in many women with PCOS. For example, in a study at Jewish Hospital in Cincinnati, 43 women who were not having periods took metformin, and 39 of them resumed normal menses.(6) In another study at Jewish Hospital, 11 teenage girls with PCOS were put on metformin and a high-protein, low-carbohydrate diet. Ten of the 11 girls resumed regular periods.(7)

IMPROVED CHANCE OF PREGNANCY. A study of 48 women with PCOS and infertility was conducted at the Baylor College of Medicine. They were first given metformin and 19 of them resumed menstruating and showed indications of ovulation. But 10 required clomiphene (a fertility drug) in addition to metformin in order to show evidence of ovulation. Twenty women of the 48 (42%) became pregnant. However, 7 of the 20 miscarried.(8)

REDUCED RISK OF MISCARRIAGE. Another aspect of PCOS-related infertility is the tendency for repeated miscarriages. A study from the Hospital de Clinicas Caracas in Venezuela looked at 65 women who received metformin during their pregnancies vs. 31 who did not. The early pregnancy (first trimester) loss rate in the metformin group was 8.8% as compared to a 41.9% loss in the untreated group. Of those women who previously had miscarried, 11.1% of the metformin group miscarried again, while 58.3% of the untreated group again miscarried. (9)

REDUCED RISK OF GESTATIONAL DIABETES. In another study at Jewish Hospital in Cincinatti, gestational diabetes risk was evaluated in two groups of PCOS women. The first group was 33 non-diabletic women who had conceived while taking metformin or took it during their pregnancy. This group was compared to a group of 39 PCOS women who did not take it. Only 3% of the metformin group developed gestational diabetes as compared to 31% in the non-metformin group.(10)

WEIGHT LOSS AND OTHER BENEFITS. Metformin may contribute to weight loss in some diabetics.(11) However, weight loss does not appear to be one of its primary benefits. Glucophage may also be of some value improving success with in vitro fertilization, lowering cholesterol, and improving energy.

http://www.ovarian-cysts-pcos.com/gl...rmin-pcos.html

Linda
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Old 07-02-2004, 01:40 PM   #4 (permalink)
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I have been on metformin for a little over two years now. I started out on 1700mg met and 8mg avandia. I got AF within two weeks. Within three months my acne had cleared up, except for the normal acne I still get with AF. Within six months I had become what I like to call PCOS symptom free. My mood swings leveled out, the hair in those embarasing places isn't growing as fast and is actually thinning out. After 12 months, my Dr upped the dose to 2000mg met and 8 mg avandia. Two months later we found out that we are expecting. I am now 25 weeks and counting. For the 14 months before I got pregnant, I "O" every cycle and my cycles were 29 days, give or take a day, but didn't go past 30 days. I had slow weight loss which is fine, but I stopped gaining that was the big thing, I believe that is because I was on the avandia too (recomended combo if ttc)I am still takeing the met and my Dr says that he wants me to stay on the met for the rest of my life, no complaints from me on that one. If I can, I will never give up my met, it has been the best thing that I have done for the treatment of my PCOS.

My little sister was DXed with PCOS three months ago and started on the met right away, I sent her with lots of info when she went, she is not ttc. She started out on 500mg met for the first week, then 1000mg the second week, and 1500mg the third week, she hasn't upped the dose again, but it took 2 1/2 months for her to get AF, her acne is almost gone and she has already lost 25 pounds. She is doing great and hasn't had any side effect, unlike me, lol, I had just about all the side effects. I am really excited about seeing her progress on the met.

Here ore some links you might want to print out and take with you.

http://www.intelligenthealthcenter.c...edpcosmeds.asp

http://www.conceivingconcepts.com/le.../pcosmeds.html

www.ivf.com/pcostreat.html

www.medanalysis.com/pdf/kuttner.pdf

most of these are about ttc but they also adress the benifets of metformin in general. Good luck, I hope you can get on the met.
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Old 07-02-2004, 05:19 PM   #5 (permalink)
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Thank you very much everyone for you replies.


I too saw someone either called Sanders or Sanderman but he was not really helpful, he said that I was only borderline PCOS and that I should just go away and loose weight. But it was about 6 years ago and I suppose things do change. My dermatologist is going to have a word with him to see if he agrees that I can give it a go. If not I think I will have a paddy throw a few things around and say "Well I hear it helps with mood swings too".

Anyway thanks again and I am not going to give up the fight as my symptoms are getting worse.

Love to all

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