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Old 04-14-2003, 09:19 PM   #1 (permalink)
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Question Q's about Spiro, Met, Yasmin etc

I had an appointment with a (completely ignorant) Gynae today and he said some weird things that I suspect aren't all true but I don't want to shoot him down in flames just in case there is some truth in what he said.

"Spironolactone is an androgen and increases certain types of androgen production in women" I was under the impression that it was an ANTI-androgen? It certainly helped my male symptoms tremendously in the 3 years I took it for PCOS.

He also said my high LH level 38.1 compared to FSH of 8.4 showed that I had "ovulated during the month in which the blood was drawn". I thought the ratio of LH to FSH should be no more than 2:1 and that my ratio of almost 5:1 is an indication of PCOS?

He also said that my "low SHBG level of 47.9 is indicative of IR". As I have been low carbing, this level has now risen to 74.5, which he says shows that my IR has improved. I am sure it has but is this really an indication of IR improvement?

He also said that there is no evidence to support that Spiro is benefical in treating PCOS! Der!! I told him how it has helped me and many other cysters and he was very surprised but I suspect sceptical too. But he has prescribed Glucophage for me which susprised me greatly but he said that it is only prescribed here in UK for women TTC for a maximum of 6 months!

He offered me the BCP Yasmin and said that it "contains Spiro" (or some components similar to Spiro). Is this true?

When he said that "dieting has absolutely no positive effect on PCOS" I hit the roof and told him he was talking crap and he then backtracked and conceded that low-carbing may be benefical to some people with PCOS!! He he! I kicked butt lol!

If any of his above statements ARE true please let me know. Thanks!

Nikki x
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Old 04-15-2003, 05:47 PM   #2 (permalink)
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Hi Nikki

((hugs)), well I've been told that Spiro IS an anti androgen, and helps with the hair. I've been on 100 per day for 2 years now.

I started Met Sept last year, and wasn't told it would only be for a few months.......

And the weight thing? Well, my Endo always goes ON about how weight loss would HELP the pcos.

btw - the Gynae I saw at the hospital, said that an Endo would be a better person to see about pcos, as they 'understand' pcos better. Could you get referred to an Endo instead??

Hope this helps

Eva
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Me 36, dh 31, son 6 years. Married 9 years.

Dx: PCOS, LOCAH, HS, Lichen Planus, IBS, raised bp, raised cholesterol

Spiro, Metformin, Bendrofluazide, Amlodapine, Atorvastatin, Prednisolone, Multi Vits, Co-Proxamol, Corsodyl

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Old 04-15-2003, 08:54 PM   #3 (permalink)
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Thans for your reply Eva,

I think he must be wrong about Spiro being an androgen because I know it is not generally prescribed to men (as a diuretic, not PCOS of course! ) because it can cause male breast growth. I was on 100mg per day for about 18 months but then was reduced down to 50mg per day, as I was having to get up 8 times per night to pee! I was worried that being on this lower dose would not have enough benefit but it seemed to continue to work just as well, although the peeing remained the same. I came off it 3 months ago after 3 years but went back on it again 2 weeks ago, as I couldn't stand the return of the hirsutism, acne and scalp hair loss, which was dramatic within 3 weeks! I noticed a slight improvement in the peeing after I came off Spiro and I assumed I would be peeing excessively again once I went back on it, but I don't get up more than once or twice now. So, I figured the peeing was more about IR, as since I began low-carbing 2 months ago the peeing has reduced considerably. I really love Spiro. I can honestly say it has been a wonder drug for me.

As to the Met, I know allowances for certain types of drugs, are sometimes regional in the UK. I feel confident that if I have good success on it that I will be able to continue with it indefinitely, as long as I see the right Dr. My GP is pretty good about these things. I think that my local hospital policy is generally to only prescribe it for people TTC but as I was pushy and well informed about things, he let me have it. But he did say it was more to do with them not knowing the longterm implications of taking Met, and he said if I want to continue with it after 6 months that it would be my own responsibilty if I got ill at a later date because of it! What a jerk! I'm sure it's more about money, costs and hospital budgets...

He said in one breath how losing weight could make all PCOS symptoms disappear for good but then went on to say that dieting has no benficial effect on PCOS (!?!) How dumb - you don't lose weight without 'dieting' in some form or other, even if you decide to make lifestyle changes, like low-carbing, you are still essentially dieting, just in a more sensible way. He basically said if I lost weight I would be cured, but I think it is more about
losing the weight because of low-carbing because my sister is thin but has PCOS as are many other cysters here. I think it's more an IR issue than a weight one. My sister is IR (undiagnosed) but won't low-carb as she says she doesn't have time to do it. I don't think she realises fully the implications of IR leading on to diabetes yet.

When my Dr first asked for my appt in January, she wrote to the Endo who referred me to one of his Gynaes I knew I would need to see an Endo but I decided to give the Gynae a chance first but he has now referred me back to the Endo for a joint appt with both of them (apparently my case is unusual lol as in I know more about what's wrong with me than he does!) which will be another 2 months wait! I've decided to write to the Endo meanwhile to update him in advance, so we both know what to expect, or else I may be delayed even further and before I know it, another year will be gone with no progress.

I haven't taken the Met yet, as I am a little nervous about the side effects in the first few days/weeks. I really want to take it but I am worried I will get awful, sudden diarrhea when I am on stage performing! I have a busy couple of weeks coming up, so I may wait a couple of weeks. I've read a lot of tips about how and when is best to take it and which remedies help the side effects but I am pretty scared. I seem to be one of those weird people who always gets the worst side effects How did you find the side effects were for you in the early days?

Anyway, I've waffled on far too long (what's new?) Thanks for the hugs too Eva.

Nikki x
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