Wednesday 25 April 2007
Resistin plays active role in PCOS
Source: Human Reproduction 2007; 22: 1100-6
Looking at serum and messenger RNA expression of resistin in women with polycystic ovary syndrome and the effects of laparoscopic ovarian electrocauterization.
Medwire News: Resistin may be actively involved in the pathogenesis of polycystic ovary syndrome (PCOS), say researchers.
They have shown that laparoscopic ovarian electocauterization (LOE) down-regulates resistin messenger (m)RNA expression both in lean and obese women with PCOS.
Kok-Min Seow (Fu-Jen Catholic University, Taipei Hsien, Taiwan) and colleagues studied adipose tissue collected from six obese and six lean women with PCOS, and 12 controls without PCOS.
Resistin mRNA expression was significantly higher in both lean and obese women with PCOS than in controls.
After LOE, levels of resistin mRNA dropped significantly to those found in control women.
Women with PCOS also showed higher levels of insulin than controls but did not have higher serum levels of resistin.
"We suggest that LOE may reduce insulin resistance in both obese and lean women with PCOS by down-regulating local resistin expression in adipocytes," say the authors.
"Resistin seems to be actively involved in the pathogenesis of PCOS by a local paracrine action."
Posted: 18 April 2007
© 2007 Current Medicine Group Ltd, a part of Springer Science+Business Media
http://www.orgyn.com/en/news/2007/We...91975331712963
Resistin plays active role in PCOS 
