There's a new diet book out called Syndrome W. Here's a brief rundown on it, plus some info from the author's website. I thought it was interesting because it involves the "off label" use of Metformin:

Syndrome W
Carb modified diet
Exercise optional
No starches until 4pm
Vegetables for breakfast, lunch, dinner
Uses Metformin to target insulin resistance

Not permitted:
Sugar
Ripe bananas
No fruit juices or dried fruits
Cereal

Q. What’s the book about?
Curing midlife weight gain.

Q. What will I get from reading it?
An entirely new approach to assessing – and reversing – midlife weight gain!

Q. Why is this book "ground-breaking?"
It explains for the very first time why most women who exercise regularly and eat reasonably and still add pounds each year have a metabolic defect that won’t go away without medication.
It outlines how permanent weight loss is finally possible with The Mogul Protocol. This easy-to-follow regimen targets the underlying metabolic defect by combining a few key dietary changes with a low cost, widely used prescription medication.
It provides simple strategies from a lifetime of treating overweight women that overcome all the obstacles of ALL overcommitted American women - Syndrome W and others.
Q. What is Syndrome W?
Syndrome W is a cluster of clinical symptoms that include weight gain, waist gain, and "white coat hyper-tension" (blood pressure increases in a doctor’s office) in women with nor-mal blood sugar and elevated insulin levels "hyperinsulinemia." It is the earliest indicator of diabetes down the road at a time when it’s easiest to fix.

Q. How common is Syndrome W?
Twenty-five percent of Americans are now obese and 25% of adults have The Metabolic Syndrome (also called Syndrome X), a combo of obesity with abnormalities in blood sugar, blood pressure and fats in the bloodstream. Almost all obese individuals have insulin resistance & hyperinsulinemia. Prior to reaching the later stages they have fewer symptons, they have Syndrome W. So we’re talking about a lot of people here.

Q. If Syndrome W is as common as you say, how come no one else described it?
The hallmark of Syndrome W is hyperinsulinemia – elevated insulin levels, either when fasting or in response to a standard glucose tolerance test. Since physicians in America don't routinely perform glucose tolerance tests or measure insulin levels (even in women and men at risk for diabetes) Syndrome W is hard to find! Q. How did you find Syndrome W?
Finding and defining Syndrome W was a culmination decades of research, a little bit of luck, and lots of things that came together for me:

a lifelong interest in obesity and metabolism, a preference for prevention, and a feminist perspective
an extraordinary education at pioneering academic institutions – Bryn Mawr College, The Albert Einstein College of Medicine, and Columbia’s School of Public Health—that encouraged observation and originality in research.
a unique opportunity to talk to and track thousands of women at important transitions (adolescence and menopause) which helped define Syndrome W and its solution.

Q. Why did you write this book? To expand obesity treatment options, educate women, enable doctors, and generate funding for large-scale studies of The Mogul Protocol in diverse Americans.

Q. Would you like to see medical practice change as a result of your findings?
Absolutely!

http://syndromew.com/pages/syndromew_faq.html